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I-Corps: Volumetric Light-Assisted Manufacturing of Dental Implants and Tissue Scaffolds

I-Corps：牙种植体和组织支架的体积光辅助制造

基本信息

批准号：
2234496
负责人：
Amir Miri
金额：
$ 5万
依托单位：
New Jersey Institute of Technology
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2023-11-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2234496&HistoricalAwards=false
关键词：
Corps Volumetric Light Assisted Manufacturing

项目摘要

The broader impact/commercial potential of this I-Corps project is the development of a biomanufacturing tool for dental products. To date, most dental implants have been made by selective application of a single starting material by making a specific mold for each case. The main limitations of such approaches are low fabrication speeds, significant labor costs, and lack of stability in materials that are produced. It is crucial to achieve a high fabricate rate and stable constructs without limiting the desired function of the implant or tissue scaffold. An ideal dental implant fabrication method should make molds within minutes. Modern 3D printing techniques and proper material selection enable this technology to rebuild portions of lost tissue.This I-Corps project is based on the development of a customizable, light-assisted, 3D printing platform that allows for quick fabrication of polymer-based inks and hydrogels. The technology will be used to fabricate stable and functional (dental) implants. Such polymeric inks are based on photoresponsive molecules in the material. This technology will use ultraviolet (UV) crosslinking of methacrylate groups in conventional hydrogels or polymer precursors for long-term stability of the selected implant. Advantages of this technology include: a modular chamber for multi-component biomaterials; very rapid fabrication of implants, scaffolds, and surgical tools; a significant level of control creation, and a low-cost product.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个i-Corps项目更广泛的影响/商业潜力是开发一种用于牙科产品的生物制造工具。到目前为止，大多数牙种植体都是通过为每种情况制作特定的模具，选择性地应用单一的起始材料来制造的。这种方法的主要局限性是制造速度低，劳动力成本高，所生产的材料缺乏稳定性。在不限制植入物或组织支架的期望功能的情况下，获得高的制造率和稳定的构造是至关重要的。一种理想的牙种植体制作方法应该在几分钟内制作出模具。现代3D打印技术和适当的材料选择使这项技术能够重建部分丢失的组织。这个i-Corps项目基于可定制的、光辅助的3D打印平台的开发，该平台允许快速制造基于聚合物的油墨和水凝胶。这项技术将被用于制造稳定和功能性的(牙科)植入物。这种聚合物油墨是基于材料中的光响应性分子。这项技术将使用传统水凝胶或聚合物前驱体中甲基丙烯酸酯基团的紫外线(UV)交联，以确保所选植入物的长期稳定性。这项技术的优势包括：用于多组分生物材料的模块化腔体；非常快速地制造植入物、支架和手术工具；显著的对照创造水平，以及低成本的产品。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。