New Anion Binders Based on Aromatic Linear and Cyclic Aromatic Oligoamides

基于芳香族线性和环状芳香族低酰胺的新型阴离子粘合剂

• 批准号: 2304878
• 负责人: Bing Gong
• 金额: $ 55万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-12-15 至 2026-11-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2304878&HistoricalAwards=false
• 关键词: New; Anion; Binders; Based; Aromatic

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry, Professor Bing Gong of the State University of New York at Buffalo will be studying designer molecules with cyclic scaffolds known as macrocycles and how they interact with anions. This research aims to further understanding of how macrocycle design can be finely tuned to build in anion specificity and to establish new ways to bind particular anions, especially for those that are important for energy and the environment. The team will also be looking at how these macrocycles can move anions through different barriers such as cell membranes or non-polar organic solutions, which could be useful in many different fields. This project will integrate molecular design with experimental studies and provide research training opportunities for undergraduate and graduate students, including students from underrepresented groups. The research results will be publicized broadly in the scientific community and incorporated into undergraduate and graduate teaching.The macrocycles being targeted herein have a constrained aromatic oligoamide backbone that enforces the convergent placement of multiple amide NH and phenyl CH groups. These NH and CH groups define an electropositive binding cavity that is highly pre-organized for binding anions. Because of their hydrogen-bonding capabilities and differences in preference for anions, the macrocycles are expected to exhibit versatile binding capabilities for anions with varying properties. The macrocycles will assist in transporting anions across cell membranes or bulk non-polar organic solvents. The efficiency and selectivity of anion transport will be assessed using established fluorescence assays including those based on vesicles (liposomes) or those using U-shaped tubes. This research team will (1) optimize and scale up the synthesis of the anion-binding macrocycles, (2) conduct systematic anion binding studies to quantify the binding affinities of the macrocycles with different anions in various solvents, and (3) examine anion transport across lipid bilayers or non-polar organic solvents to determine the efficiencies and selectivity of transporting homologous series anions, such as halides and oxoanions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系大分子、超分子和纳米化学项目的支持下，纽约州立大学布法罗分校的龚兵教授将研究具有环状支架的设计分子，即大环，以及它们如何与阴离子相互作用。本研究旨在进一步了解如何微调大周期设计以构建阴离子特异性，并建立结合特定阴离子的新方法，特别是对于那些对能源和环境重要的阴离子。该团队还将研究这些大环如何使阴离子通过不同的屏障，如细胞膜或非极性有机溶液，这在许多不同的领域都是有用的。该项目将分子设计与实验研究相结合，并为本科生和研究生提供研究训练机会，包括来自代表性不足群体的学生。研究成果将在科学界广泛宣传，并纳入本科和研究生教学。本文所针对的大环具有约束的芳族低聚酰胺骨架，强制多个酰胺NH和苯基CH基团的收敛放置。这些NH和CH基团定义了一个高度预先组织的结合阴离子的电正结合腔。由于它们的氢键能力和对阴离子的偏好差异，大环有望对不同性质的阴离子表现出通用的结合能力。大环将有助于在细胞膜或散装非极性有机溶剂中运输阴离子。阴离子运输的效率和选择性将使用已建立的荧光分析进行评估，包括基于囊泡（脂质体）或使用u形管的荧光分析。本研究团队将(1)优化并扩大阴离子结合大环的合成规模；(2)进行系统的阴离子结合研究，量化大环在不同溶剂中与不同阴离子的结合亲合力；(3)研究阴离子在脂质双分子层或非极性有机溶剂中的转运，以确定转运同源系列阴离子（如卤化物和氧阴离子）的效率和选择性。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。