Analytical Studies Using Ionic Liquids, GUMBOS, and nanoGUMBOS

使用离子液体、GUMBOS 和 nanoGUMBOS 进行分析研究

• 批准号: 2309879
• 负责人: Isiah Warner
• 金额: $ 36万
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2309879&HistoricalAwards=false
• 关键词: Analytical; Studies; Using; Ionic; Liquids

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professors Isiah Warner, Jin-Woo Choi, and Kevin McCarter and their groups at Louisiana State University are using liquid and solid organic salts as the basis for new kinds of chemical sensors for important and biomedically relevant analytes. These solid phase salts are being formulated as nanomaterials to enable additional analytical applications. The probe involves coupling the salts with a "quartz crystal microbalance" (QCM) - an instrument normally used for simply weighing minute amounts of materials, but in this case providing selective sensing based on the selective interactions of the salts with target analytes. Miniature versions of this novel instrumentation are being developed to enable use as portable sensors for analyses of volatile analytes. The work exposes a diverse group of students to state-of-the-art research in chemical instrumentation through research opportunities and extensive public outreach.These studies focus on ionic liquids and solid-state materials derived from a "Group of Uniform Materials Based on Organic Salts" (GUMBOS), including nanomaterials derived from GUMBOS (nanoGUMBOS). The nanoGUMBOS can be safe and effective alternatives relative to many current nanomaterials used for bioanalytical applications. The work targets novel, useful, and environmentally friendly analytical applications. For example, strategies are being developed for selective measurement of analytically important biomedical targets through novel solvent and solid phase extractions. In combination with the QCM, the GUMBOs can serve in sensors using multiple analytical strategies. Novel QCM micro-instrumentation is being developed to enhance the range of analytical applications for this methodology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学测量和成像项目的支持下，路易斯安那州立大学的Isiah Warner、Jin-Woo Choi和Kevin McCarter教授及其团队正在使用液体和固体有机盐作为新型化学传感器的基础，用于重要的生物医学相关分析。这些固相盐正被配制成纳米材料，以实现额外的分析应用。探针涉及到将盐与“石英晶体微天平”（QCM）耦合，这种仪器通常用于简单地称重微量材料，但在这种情况下，根据盐与目标分析物的选择性相互作用提供选择性传感。这种新型仪器的微型版本正在开发中，可以用作分析挥发性分析物的便携式传感器。这项工作通过研究机会和广泛的公众宣传，使不同群体的学生接触到最先进的化学仪器研究。这些研究集中在离子液体和固态材料上，这些材料来源于“基于有机盐的均匀材料组”（GUMBOS），包括来源于GUMBOS的纳米材料（nanoGUMBOS）。相对于目前用于生物分析应用的许多纳米材料，nanoGUMBOS可以是安全有效的替代品。这项工作的目标是新颖、有用和环保的分析应用。例如，正在开发通过新型溶剂和固相萃取选择性测量分析重要生物医学目标的策略。结合QCM， GUMBOs可以在传感器中使用多种分析策略。新型QCM微型仪器正在开发中，以增强该方法的分析应用范围。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。