CAREER: Regulating Vulnerability: Reproduction, Risk, and the Social Production of Biomedical Research Ethics

.________________________________________________________________________________________________________________ 该职业项目研究了随着时间的推移，有关产科患者和生物医学研究的监管变化。这样做，它有助于推动有关研究法规和科学知识生产的目标和后果的紧迫科学、医学、伦理和政策讨论。该项目还阐明了生殖知识的产生如何影响健康和健康差异。该项目的教育计划以扩大科学技术研究和伦理学的教学为中心。它将为即将进入应用研究、临床工作、公共部门职位和学术界的学生提供批判性评估、管理和研究人口健康和研究伦理方面关键问题的生产性培训。该项目的更广泛影响还包括制作白皮书、培训研究生以及召开跨学科研讨会，以促进有关复制和研究的学术和公众对话。该项目将引起生物医学研究人员、产科患者及其家人、生物医学领域的教育工作者和医疗政策制定者的兴趣。该项目利用多种方法，包括档案研究、内容分析、口述历史、民族志观察以及专家和多个利益相关群体的访谈，记录了与产科患者有关的研究法规过去和现在的变化，并分析了利益相关者如何应对与生殖相关的监管修订。它提出的问题是：过去八年里，哪些社会、文化、政治和伦理因素影响了有关产科患者的研究法规？如何接受、部署和实施有关产科患者和临床研究的监管类别的变化？利益相关者如何应对生殖和生物医学研究背景下的文化、伦理和监管变化？在回答这些问题时，该项目增强了对医学历史和社会学的基本理解，并推进了有关知识生产过程和监管变革结果的科学和技术研究理论。该项目还增加了学术界和公众对人类受试者研究的伦理和道德的理解，并为科学研究和生物伦理学交叉点的伦理社会生产构建了理论框架。组织全国研讨会使该项目能够将科学研究奖学金与有关生殖和生物伦理学的更广泛对话联系起来。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

.______________________________________________________________________________________________________________________This CAREER project examines regulatory changes regarding obstetric patients and biomedical research over time. In so doing, it contributes to pressing scientific, medical, ethical, and policy discussions about the goals and consequences of research regulations and scientific knowledge production. The project also elucidates how the production of knowledge about reproduction matters for health and health disparities. This project's education plan centers on expanding instruction in science and technology studies and ethics. It will offer students who will be going into applied research, clinical work, public sector positions, and academia productive training for critically assessing, managing, and studying key issues in population health and research ethics. The broader impacts of this project also include producing white papers, training graduate students, and convening an interdisciplinary workshop that advances academic and public dialogue about reproduction and research. This project will be of interest to biomedical researchers, obstetric patients and their families, educators in the biomedical field and medical policy makers.Drawing on multiple methods, including archival research, content analysis, oral histories, ethnographic observations, and interviews with experts and multiple stakeholder groups, this project documents past and present changes in research regulations pertaining to obstetric patients, and it analyzes how stakeholders respond to regulatory revisions related to reproduction. It asks: What social, cultural, political, and ethical factors have influenced research regulations regarding obstetric patients over the past eight decades? How do changes in regulatory categories with respect to obstetric patients and clinical research get taken up, deployed, and implemented? How do stakeholders respond to cultural, ethical, and regulatory changes in the context of reproduction and biomedical research? In answering these questions, this project enhances basic understanding within the history and sociology of medical science, and advances theory in science and technology studies about processes of knowledge production and outcomes of regulatory change. This project also increases scholarly and public understandings of the ethics and morality of human subjects research and builds a theoretical framework for the social production of ethics at the intersection of science studies and bioethics. Organizing a national workshop enables this project to bridge science studies scholarship with wider conversations about reproduction and bioethics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.