CAREER: Regulating Vulnerability: Reproduction, Risk, and the Social Production of Biomedical Research Ethics

.______________________________________________________________________________________________________________________这个CAREER项目研究了随着时间的推移，产科患者和生物医学研究的监管变化。在这样做的过程中，它有助于推动关于研究法规和科学知识生产的目标和后果的科学，医学，伦理和政策讨论。该项目还阐明了生殖知识的产生如何影响健康和健康差距。该项目的教育计划集中在扩大科学技术研究和道德方面的教学。它将为即将进入应用研究，临床工作，公共部门职位和学术界生产培训的学生提供批判性评估，管理和研究人口健康和研究伦理的关键问题。该项目的更广泛影响还包括制作白色论文，培训研究生，并召开跨学科研讨会，推动关于生殖和研究的学术和公众对话。该项目将引起生物医学研究人员、产科患者及其家属、生物医学领域的教育工作者和医疗政策制定者的兴趣，利用多种方法，包括档案研究、内容分析、口述历史、人种学观察以及与专家和多个利益攸关方团体的访谈，该项目记录了过去和现在与产科患者有关的研究法规的变化，并分析了利益相关者如何应对与生殖有关的法规修订。它问道：在过去的80年里，什么样的社会、文化、政治和伦理因素影响了关于产科患者的研究规定？产科患者和临床研究监管类别的变化如何被采纳、部署和实施？利益相关者如何应对生殖和生物医学研究背景下的文化，伦理和监管变化？在回答这些问题时，本项目加强了对医学科学的历史和社会学的基本理解，并推进了关于知识生产过程和监管变化结果的科学和技术研究理论。该项目还增加了学术界和公众对人类受试者研究的伦理和道德的理解，并在科学研究和生物伦理学的交叉点上为伦理的社会生产建立了理论框架。组织一次全国性的研讨会使该项目能够将科学研究奖学金与更广泛的生殖和生物伦理学对话联系起来。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

.______________________________________________________________________________________________________________________This CAREER project examines regulatory changes regarding obstetric patients and biomedical research over time. In so doing, it contributes to pressing scientific, medical, ethical, and policy discussions about the goals and consequences of research regulations and scientific knowledge production. The project also elucidates how the production of knowledge about reproduction matters for health and health disparities. This project's education plan centers on expanding instruction in science and technology studies and ethics. It will offer students who will be going into applied research, clinical work, public sector positions, and academia productive training for critically assessing, managing, and studying key issues in population health and research ethics. The broader impacts of this project also include producing white papers, training graduate students, and convening an interdisciplinary workshop that advances academic and public dialogue about reproduction and research. This project will be of interest to biomedical researchers, obstetric patients and their families, educators in the biomedical field and medical policy makers.Drawing on multiple methods, including archival research, content analysis, oral histories, ethnographic observations, and interviews with experts and multiple stakeholder groups, this project documents past and present changes in research regulations pertaining to obstetric patients, and it analyzes how stakeholders respond to regulatory revisions related to reproduction. It asks: What social, cultural, political, and ethical factors have influenced research regulations regarding obstetric patients over the past eight decades? How do changes in regulatory categories with respect to obstetric patients and clinical research get taken up, deployed, and implemented? How do stakeholders respond to cultural, ethical, and regulatory changes in the context of reproduction and biomedical research? In answering these questions, this project enhances basic understanding within the history and sociology of medical science, and advances theory in science and technology studies about processes of knowledge production and outcomes of regulatory change. This project also increases scholarly and public understandings of the ethics and morality of human subjects research and builds a theoretical framework for the social production of ethics at the intersection of science studies and bioethics. Organizing a national workshop enables this project to bridge science studies scholarship with wider conversations about reproduction and bioethics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.