New cyclic peptoids - design and syntheses

新的环状类肽 - 设计和合成

• 批准号: 260963601
• 负责人: Professor Dr. Stefan Bräse
• 金额: --
• 依托单位: Institut für Organische Chemie (IOC)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/260963601?language=en
• 关键词: New; cyclic; peptoids; design; syntheses

For over 30 years, peptoids are a well-known class of compounds. Since then, they are constantly developed. Due to their fast and easy synthesis, peptoids represent popular mimetics that can be used in many ways. Through the correlation of efficacy and structure the basic research focusses on the development of individual structural motifs that mimic known peptide structures. On the basis of successful preliminary work, the aim of this project is to develop novel tertiary structures of peptoid scaffolds, which later serve for the complexation of metals. Furthermore, we intend to advance ligand systems that specifically bind metals and allow simple and simultaneous incorporation into this newly generated scaffolds.

30多年来，类肽是一类众所周知的化合物。从那时起，它们不断发展。由于其快速和容易的合成，类肽代表了可以以多种方式使用的流行模拟物。通过功效和结构的相关性，基础研究集中在模拟已知肽结构的单个结构基序的开发上。 在成功的前期工作的基础上，本项目的目标是开发新型的类肽支架的三级结构，随后用于金属的络合。此外，我们打算推进配体系统，专门结合金属，并允许简单和同时纳入到这个新产生的支架。