New cyclic peptoids - design and syntheses

30多年来，类肽是一类众所周知的化合物。从那时起，它们不断发展。由于它们的快速和容易的合成，肽代表了流行的模仿物，可以在许多方面使用。通过有效性和结构的相关性，基础研究集中在模仿已知肽结构的单个结构基序的开发上。在成功的前期工作的基础上，本项目的目标是开发新的肽类支架的三级结构，用于金属络合。此外，我们打算推进专门结合金属的配体系统，并允许简单地同时结合到这种新生成的支架中。

For over 30 years, peptoids are a well-known class of compounds. Since then, they are constantly developed. Due to their fast and easy synthesis, peptoids represent popular mimetics that can be used in many ways. Through the correlation of efficacy and structure the basic research focusses on the development of individual structural motifs that mimic known peptide structures. On the basis of successful preliminary work, the aim of this project is to develop novel tertiary structures of peptoid scaffolds, which later serve for the complexation of metals. Furthermore, we intend to advance ligand systems that specifically bind metals and allow simple and simultaneous incorporation into this newly generated scaffolds.