Asymmetric synthesis of oxygen heterocycles with planar-chiral organo-catalysts Synthesis - Catalysis - Theory

平面手性有机催化剂不对称合成氧杂环 合成-催化-理论

• 批准号: 53715404
• 负责人: Professor Dr. Stefan Bräse
• 金额: --
• 依托单位: Institut für Organische Chemie (IOC)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/53715404?language=en
• 关键词: Asymmetric; synthesis; oxygen; heterocycles; planar

In this joint proposal, an international team consisting of three groups (Erase, Zipse, Shi) are jointly working on the application of planar-chiral organocatalysts towards the synthesis of enantiomerically pure heterocycles. Based on preliminary published examples from this team, a "green" approach avoiding any transition-metals is made. Since the design of the novel catalysts is crucial at this point, in-depth theoretical calculation is backing up this part. Extensive exchange of graduate and postgraduate students is implemented in this program.

在这项联合提案中，一个由三个基团(ERASE，ZIPSE，SHI)组成的国际团队正在共同致力于平面手性有机催化剂在合成对映体纯杂环方面的应用。根据该团队已发表的初步实例，提出了一种避免任何过渡金属的“绿色”方法。由于新型催化剂的设计在这一点上至关重要，因此这一部分需要进行深入的理论计算。该项目实施了研究生和研究生的广泛交流。