Compounds Platform (ComPlat): Management, storage and sharing of chemical compounds: Installation of an interdisciplinary compound-facility to open available resources of research groups to scientists for a long-term usage and to initiate novel collaborat

化合物平台（ComPlat）：化合物的管理、存储和共享：安装跨学科化合物设施，向科学家开放研究小组的可用资源，供其长期使用并启动新颖的合作

• 批准号: 284178167
• 负责人: Professor Dr. Stefan Bräse
• 金额: --
• 依托单位: Institut für Organische Chemie (IOC)
• 依托单位国家: 德国
• 项目类别: Core Facilities
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/284178167?language=en
• 关键词: Compounds; Platform; ComPlat; Management; storage

We aim to install a national, but international in the long term, institution named ComPlat at the Karlsruhe Institute of Technology (KIT) that manages the preservation and research-related usage of compounds that have been produced in different academic projects. During the first year of the funding period, the initial requirements for the project will be installed and the operation of the platform will be shown for only a few additional universities in addition to the current user group. Later in the second and third year, the Compounds Platform (ComPlat) will be open nationwide for interested universities and single research groups, and if the capacity allows it, then additional international requests will be accepted as well. The new institution will prevent chemical compounds, which should be considered as highly valuable species, to be protected and to be reused, rather than sinking into oblivion and not being available for further research. While molecules with lead-like character are searched and used by many (international) institutions, which are defined as compound storage or screening facilities, the Compound Platform (ComPlat) will not focus only on the trendy, preselected types of molecules for pharmaceutical development, but on every stable compound. The submitted molecules will be indexed, stored and offered on demand to guarantee access to a virtual and physical platform for the exchange and sharing of research results for on the hand research groups with the need of particular compounds and on the other hand synthetic chemists. The platform will preserve reference material, support the realization of research projects with high need of chemical entities (e.g. screening) and will offer compounds for preliminary work to initiate new collaborations. The procedure that has been established successfully in Karlsruhe will be extended to selected national and international groups through the herein applied funding to enable the participation of a larger community of users and to give access to all academic researchers to this novel level of platform. The equipment fleet needed to handle, store, manage, but also perform the quality control, the purification and the distribution of the compounds, as well as the essential staff are already available for free. The development plan covers the following modules, which will enable the extension of the KIT-platform and the efficient use of the infrastructures: (1) support concerning legal affairs (generation of basic contracts as e.g. material transfer agreements), (2) offer and distribute glassware to the partner universities/collaborating groups (logistics), (3) operate an online platform to register compounds and a virtual compound library, (4) preserve and index the submitted compounds, (5) analysis, (6) distribute services and compound handling, (7) use and operation of the equipment required for points (3)-(6).

我们的目标是在卡尔斯鲁厄理工学院（KIT）建立一个名为ComPlat的国家级但从长远来看是国际性的机构，负责管理不同学术项目中生产的化合物的保存和研究相关用途。在资助期的第一年，将安装项目的初始要求，并将显示除当前用户群外的其他几所大学的平台运行情况。在第二年和第三年的晚些时候，化合物平台（Compounds Platform）将在全国范围内向感兴趣的大学和单个研究小组开放，如果能力允许，还将接受其他国际申请。新机构将防止应被视为高度宝贵物种的化合物得到保护和再利用，而不是沉入遗忘，无法用于进一步研究。虽然许多（国际）机构（定义为化合物储存或筛选设施）都在搜索和使用具有铅样特征的分子，但化合物平台（Compound Platform）将不仅关注用于药物开发的时尚预选分子类型，而且关注每一种稳定的化合物。提交的分子将被索引，存储和按需提供，以保证访问一个虚拟和物理平台，以交换和共享研究结果，一方面是需要特定化合物的研究小组，另一方面是合成化学家。该平台将保存参考材料，支持实现对化学实体有高度需求的研究项目（例如筛选），并将为启动新合作的初步工作提供化合物。在卡尔斯鲁厄成功建立的程序将通过此处申请的资金扩展到选定的国家和国际团体，以使更大的用户社区能够参与，并使所有学术研究人员都能使用这一新水平的平台。处理、储存、管理以及执行质量控制、纯化和分配化合物所需的设备队以及基本工作人员已经免费提供。开发计划包括以下模块，这些模块将能够扩展KIT平台并有效利用基础设施：（一）法律的事务支持（制定基本合同，如材料转让协议），（2）向合作大学/合作团体提供和分发玻璃器皿（物流），（3）操作在线平台以注册化合物和虚拟化合物库，（4）保存和索引提交的化合物，（5）分析，（6）分发服务和化合物处理，（7）第（3）-（6）点所需设备的使用和操作。