Iron-catalyzed carbene insertions

铁催化卡宾插入

• 批准号: 270580108
• 负责人: Professor Dr. Bernd Plietker
• 金额: --
• 依托单位: Professur für Organische Chemie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/270580108?language=en
• 关键词: Iron; catalyzed; carbene; insertions

In the present proposal we present a programm that aims to use electron-rich Fe-complexes for the activation of diazocompounds in X-H-insertion reactions. Based on preliminary studies, in which we were able to show that Bu4N[Fe(CO)3(NO)] as a catalyst activates ethyldiazoacetate (EDA) as a carbenoid for the insertion into N-H and S-H-bonds, the scope and limitations of these reactions shall be systematically explored . Subsequently, the corresponding insertion into the less reactive C-H-bond are targeted. Apart from the activaiton of sigma-bonds the insertion into pi-bonds (alkenes, carbonyl groups, imines, etc.) will also be investigated.

本文提出了一个利用富电子铁配合物活化重氮化合物进行X-H-插入反应的方案。基于初步的研究，我们能够表明Bu 4 N [Fe（CO）3（NO）]作为催化剂活化重氮乙酸乙酯（EDA）作为类卡宾插入N-H和S-H键，这些反应的范围和局限性将被系统地探索。随后，靶向相应插入到反应性较低的C-H键中。除了σ键的活化外，插入π键（烯烃、羰基、亚胺等）也将被调查。

项目成果

Scope and Limitations of TBA[Fe]‐Catalyzed Carbene Transfer to X−H‐bonds – Indication of a Mechanistic Dichotomy

• DOI: 10.1002/cctc.201900459
• 发表时间: 2019-11
• 期刊: ChemCatChem
• 影响因子: 4.5
• 作者: Annika Röske;I. Alt;B. Plietker