Development of Fe-catalyzed non-oxidative C-H-aminations

Fe催化非氧化性C-H胺化的发展

• 批准号: 350173462
• 负责人: Professor Dr. Bernd Plietker
• 金额: --
• 依托单位: Professur für Organische Chemie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/350173462?language=en
• 关键词: Development; Fe; catalyzed; non; oxidative

Based on results that we reported in the field of Bu4N[Fe(CO)3(NO)]-catalyzed intramolecular aminations of C(sp2)-H- and C(sp3)-H-bonds using arylazides (C(sp2Ar)-N3) the project describes a programme aiming to systematically expand this reaction to the amination of C(sp2)-H- and C(sp3)-H-bond using alkylazides both in an intra- and intermolecular fashion. The direct intermolecular amination of aromatic substrates offers an efficient access to arylamines, however in the field of Fe-catalysis this transformation is underdeveloped. The investigations aim to systematically identify appropriate azides for this kind of transformation, which shall be employed in subsequent studies in the directed amination of aromatic substrates. Different directing groups will be used in order to achieve a high degree of ortho-selectivity. It is the ultimate goal of this research project to develop a protocol for the intermolecular amination of non-functionalized alkanes. This field and the corresponding field of the directed or non-directed aromatic C-H-amination using Fe-catalysts is yet unexplored.

基于我们在Bu4N[Fe(CO)3(NO)]催化的C(Sp2)-H-和C(Sp3)-H-键分子内胺化(C(Sp2Ar)-N3)领域的研究结果，本项目描述了一个计划，旨在系统地将该反应扩展到C(Sp2)-H-和C(Sp3)-H-键的胺化反应，包括分子内和分子间的方式。芳香族底物的直接分子间胺化反应为芳香胺的合成提供了一条有效途径，但在铁催化领域，这种转化还不是很成熟。这些研究的目的是系统地确定适合这种转化的叠氮化物，这些叠氮化物将用于芳香族底物的定向胺化反应的后续研究。将使用不同的导向基团以实现高度的邻位选择性。本研究项目的最终目标是开发一种用于非官能化烷烃分子间胺化反应的协议。这一领域以及使用铁催化剂进行定向或非定向芳香族C-H-胺化反应的相关领域尚未被探索。