Development of Fe-catalyzed non-oxidative C-H-aminations

基于我们在Bu 4 N [Fe（CO）3（NO）]催化的使用芳基叠氮化物（C（sp2 Ar）-N3）的C（sp2）-H-和C（sp3）-H-键的分子内胺化领域中报道的结果，该项目描述了一个计划，旨在系统地将该反应扩展到使用烷基叠氮化物以分子内和分子间的方式胺化C（sp2）-H-和C（sp3）-H-键。芳族底物的分子间直接胺化提供了一种有效的芳胺化途径，然而在铁催化领域，这种转化尚不发达。调查的目的是系统地确定适当的叠氮化物这种转化，这将在随后的研究中，在芳香族底物的直接胺化。将使用不同的导向基团以实现高度的邻位选择性。本研究的最终目标是开发一种非官能化烷烃分子间胺化的方法。该领域和使用Fe催化剂的定向或非定向芳族C-H-胺化的相应领域尚未开发。

Based on results that we reported in the field of Bu4N[Fe(CO)3(NO)]-catalyzed intramolecular aminations of C(sp2)-H- and C(sp3)-H-bonds using arylazides (C(sp2Ar)-N3) the project describes a programme aiming to systematically expand this reaction to the amination of C(sp2)-H- and C(sp3)-H-bond using alkylazides both in an intra- and intermolecular fashion. The direct intermolecular amination of aromatic substrates offers an efficient access to arylamines, however in the field of Fe-catalysis this transformation is underdeveloped. The investigations aim to systematically identify appropriate azides for this kind of transformation, which shall be employed in subsequent studies in the directed amination of aromatic substrates. Different directing groups will be used in order to achieve a high degree of ortho-selectivity. It is the ultimate goal of this research project to develop a protocol for the intermolecular amination of non-functionalized alkanes. This field and the corresponding field of the directed or non-directed aromatic C-H-amination using Fe-catalysts is yet unexplored.