Development of Fe-catalyzed non-oxidative C-H-aminations

Fe催化非氧化性C-H胺化的发展

• 批准号: 350173462
• 负责人: Professor Dr. Bernd Plietker
• 金额: --
• 依托单位: Professur für Organische Chemie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/350173462?language=en
• 关键词: Development; Fe; catalyzed; non; oxidative

Based on results that we reported in the field of Bu4N[Fe(CO)3(NO)]-catalyzed intramolecular aminations of C(sp2)-H- and C(sp3)-H-bonds using arylazides (C(sp2Ar)-N3) the project describes a programme aiming to systematically expand this reaction to the amination of C(sp2)-H- and C(sp3)-H-bond using alkylazides both in an intra- and intermolecular fashion. The direct intermolecular amination of aromatic substrates offers an efficient access to arylamines, however in the field of Fe-catalysis this transformation is underdeveloped. The investigations aim to systematically identify appropriate azides for this kind of transformation, which shall be employed in subsequent studies in the directed amination of aromatic substrates. Different directing groups will be used in order to achieve a high degree of ortho-selectivity. It is the ultimate goal of this research project to develop a protocol for the intermolecular amination of non-functionalized alkanes. This field and the corresponding field of the directed or non-directed aromatic C-H-amination using Fe-catalysts is yet unexplored.

根据我们在BU4N [Fe（CO）3（no）]领域报告的结果，催化了C（sp2）-H和C（SP3）H键的分子内氨和使用Arylazides（c（sp2AR）-n3），该项目旨在使用该计划进行系统地扩展对C（SP3）的反应（SP3）-H-H-H-H-H-H-H-H-H-H-H-H键。一种分子间和分子间的方式。芳族底物的直接分子氨基化提供了有效的芳基胺的访问，但是在FE催化的领域，这种转化尚未发育。该研究旨在系统地确定这种转化的适当叠氮化物，应在随后的研究中用于芳香族底物的胺化。将使用不同的指导组来达到高度的正态。这是该研究项目的最终目标，是为非官能化烷烃的分子间胺化制定协议。使用Fe-atalysts的定向或非导向芳族C-H降解的该磁场和相应的场尚未探索。