1. Total Synthesis of Vinigrol Using a New Strategic Concept,2. Asymmetric Alkynyl-Substituted Trimethylenemethane [6+3] Cycloadditions,3. Total Synthesis of Bryostatin 3 Using a New Strategic Concept

1.采用新战略理念的Vinigrol全合成，2。

• 批准号: 273747462
• 负责人: Dr. Olesya Kuzmina, Ph.D.
• 金额: --
• 依托单位: Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/273747462?language=en
• 关键词: 1.; Total; Synthesis; Vinigrol; Using

In summary, we envisage a Trost asymmetric Pd-TMM reaction followed by a novel ring expansion process as the key steps to provide an efficient route to a natural product - vinigrol. Additionally, our synthetic program will examine the scope of an important class of electrocyclic reactions, namely [6+3] cycloaddition with novel TMM donors (trimethylenemethane derivatives) and acceptors, which have not been tested previously, expanding the scope of asymmetric Pd-TMM reactions. This will pave the way to a more straightforward syntheses of bioactive molecules containing bicyclic core structures. This new synthesis involving an unprecedented type of strategy will also offer the prospect of easily making analogues not available by the existing routes.

总之，我们设想了一个Trost不对称Pd-TMM反应，然后是一个新的扩环过程的关键步骤，以提供一个有效的途径，天然产物- vinigrol。此外，我们的合成计划将研究一类重要的电环化反应的范围，即[6+3]环加成与新的TMM供体（三亚甲基甲烷衍生物）和受体，这还没有被测试过，扩大不对称Pd-TMM反应的范围。这将为更直接地合成含有双环核心结构的生物活性分子铺平道路。这种涉及前所未有的策略类型的新合成也将提供容易地制造现有路线不可用的类似物的前景。

项目成果

Chemoselective chromium(II)-catalyzed cross-coupling reactions of dichlorinated heteroaromatics with functionalized aryl grignard reagents.

• DOI: 10.1002/chem.201405275
• 发表时间: 2015-01
• 期刊: Chemistry
• 作者: A. Steib;O. Kuzmina;Sarah Fernandez;Sushant Malhotra;P. Knochel

Chromium(II)-Catalyzed Amination of N-Heterocyclic Chlorides with Magnesium Amides

• DOI: 10.1055/s-0034-1380178
• 发表时间: 2015-02
• 期刊: Synlett
• 影响因子: 2
• 作者: A. Steib;Sarah Fernandez;O. Kuzmina;Martin Corpet;C. Gosmini;P. Knochel

Synthesis of novel 14-membered cyclic bis-semicarbazones

新型14元环状双缩氨基脲的合成

• DOI: 10.1016/j.tetlet.2014.08.016
• 发表时间: 2014
• 期刊: Tetrahedron Letters
• 影响因子: 1.8
• 作者: Shutalev;Fesenko;Kuzmina;Chernyshev;V. V. ;Zamilatskov
• 通讯作者: Zamilatskov