1. Total Synthesis of Vinigrol Using a New Strategic Concept,2. Asymmetric Alkynyl-Substituted Trimethylenemethane [6+3] Cycloadditions,3. Total Synthesis of Bryostatin 3 Using a New Strategic Concept

总之，我们设想了一个Trost不对称Pd-TMM反应，然后是一个新的扩环过程的关键步骤，以提供一个有效的途径，天然产物- vinigrol。此外，我们的合成计划将研究一类重要的电环化反应的范围，即[6+3]环加成与新的TMM供体（三亚甲基甲烷衍生物）和受体，这还没有被测试过，扩大不对称Pd-TMM反应的范围。这将为更直接地合成含有双环核心结构的生物活性分子铺平道路。这种涉及前所未有的策略类型的新合成也将提供容易地制造现有路线不可用的类似物的前景。

In summary, we envisage a Trost asymmetric Pd-TMM reaction followed by a novel ring expansion process as the key steps to provide an efficient route to a natural product - vinigrol. Additionally, our synthetic program will examine the scope of an important class of electrocyclic reactions, namely [6+3] cycloaddition with novel TMM donors (trimethylenemethane derivatives) and acceptors, which have not been tested previously, expanding the scope of asymmetric Pd-TMM reactions. This will pave the way to a more straightforward syntheses of bioactive molecules containing bicyclic core structures. This new synthesis involving an unprecedented type of strategy will also offer the prospect of easily making analogues not available by the existing routes.