The Total Synthesis of the Host Selective Elicitors, Syringolides 1 and 2 and Their Application in the Molecular Cloning of a Soybean Disease Resistance Gene

这项研究的重点是紫丁香内酯和丁香内酯类似物的合成，这是一种已知能在植物中引发抗病的化合物。这些合成的分子将被用来分离和表征它们的受体蛋白。最终目标是对负责产生受体蛋白的抗性基因进行分子克隆。这项研究对开发新的作物保护方法具有重要的潜力。教育计划的重点是本科课程的发展。通过这一职业奖，合成有机计划支持耶鲁大学化学系约翰·L·伍德博士的研究和教育活动。伍德教授将把他的研究重点放在了解微生物-植物信号转导以及导致植物防御超敏反应机制的生化事件上。这项工作对农业产业具有重要的潜力。伍德博士的教育计划侧重于本科生水平的课程发展。

This research focuses on the synthesis of syringolides and syringolide analogs, compounds of a type known to trigger disease resistance in plants. These synthetic molecules will be used to isolate and structurally characterize their receptor proteins. The ultimate goal is the molecular cloning of the resistance gene responsible for producing the receptor protein. The research has important potential for developing new methods of crop protection. The educational plan focuses on undergraduate course development. With this CAREER award, the Synthetic Organic Program is supporting the research and educational activities of Dr. John L. Wood of the Department of Chemistry at Yale University. Professor Wood will focus his research efforts on understanding microbial-plant signal transduction as well as the biochemical events leading to the hypersensitive response mechanism of plant defenses. The work has important potential for the agricultural industry. Dr. Wood's educational plan focuses on course development at the undergraduate level.