The Total Synthesis of the Host Selective Elicitors, Syringolides 1 and 2 and Their Application in the Molecular Cloning of a Soybean Disease Resistance Gene

宿主选择性诱导子紫丁香内酯1和2的全合成及其在大豆抗病基因分子克隆中的应用

• 批准号: 9624805
• 负责人: John Wood
• 金额: $ 33.69万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9624805&HistoricalAwards=false
• 关键词: Total; Synthesis; Host; Selective; Elicitors

This research focuses on the synthesis of syringolides and syringolide analogs, compounds of a type known to trigger disease resistance in plants. These synthetic molecules will be used to isolate and structurally characterize their receptor proteins. The ultimate goal is the molecular cloning of the resistance gene responsible for producing the receptor protein. The research has important potential for developing new methods of crop protection. The educational plan focuses on undergraduate course development. With this CAREER award, the Synthetic Organic Program is supporting the research and educational activities of Dr. John L. Wood of the Department of Chemistry at Yale University. Professor Wood will focus his research efforts on understanding microbial-plant signal transduction as well as the biochemical events leading to the hypersensitive response mechanism of plant defenses. The work has important potential for the agricultural industry. Dr. Wood's educational plan focuses on course development at the undergraduate level.

本论文主要研究了黄芩苷内酯和黄芩苷的合成 类似物，已知可引发疾病抗性的化合物， 植物 这些合成分子将用于分离和 从结构上表征它们的受体蛋白。 最终目标是 分子克隆的抗性基因负责生产 受体蛋白。 这项研究具有重要的潜力， 开发新的作物保护方法。 教育计划重点 本科课程的发展。 有了这个职业奖， 合成有机计划是支持研究和教育 约翰·L博士的活动耶鲁大学化学系的伍德 大学 伍德教授将把他的研究重点放在 了解微生物-植物信号转导以及 导致过敏反应机制的生化事件 植物防御 这项工作对农业具有重要的潜力。 行业 伍德博士的教育计划侧重于课程开发， 本科水平。