Is Syndecan-1 the mediator of the fine regulation of embryonic invasion depth by means of apoptosis and the related decision on regular or pathological implantation in humans and mice?

Syndecan-1 是否是通过细胞凋亡对胚胎侵袭深度进行精细调节的介质以及对人类和小鼠的正常或病理植入的相关决定？

• 批准号: 279029807
• 负责人: Professorin Dr. Alexandra P. Bielfeld
• 金额: --
• 依托单位: Klinik für Frauenheilkunde und Geburtshilfe
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/279029807?language=en
• 关键词: Syndecan; mediator; fine; regulation; embryonic

Within the project represented the embryonic implantation into the maternal endometrium as an interface on the course of pregnancy is supposed to be examined . The invasion depth of the conceptus into the maternal endometrial stroma is of paramount importance. Too low invasion in the sense of "shallow implantation" can lead to life-threatening diseases of mother and child during pregnancy. Equally dangerous is an excessive invasion, which can cause placenta detachment problems possibly leading to life-threatening situations during and after child birth. That the control of implantation is often not carried out correctly describes a study showing that in fact 60% of conceptions in the early and mostly undiscovered pre-clinical stages of pregnancy do not develop correctly. Since the operation of an adequate placentation and implantation are not fully understood so far, the cellular mechanisms underlying the regulation of the exact depth of invasion shall be investigated herein. Therefore, the question of how the space needed for a proper implantation of the embryo in the maternal tissue is created and how the correct regulation of invasion depth is orchestered is supposed to be answered . The chemokine receptor Syndecan-1 appears to play a role in the course of embryonic implantation, especially in the mediation of apoptosis. Herein it will be clarified which signaling pathways Syndecan-1 utilizes to induce apoptosis and how it regulates therewith the invasion depth of the conceptus to facilitate a proper implantation. Furthermore, it should be investigated, whether a dysregulated Syndecan-1 expression may provoke the onset of pregnancy disorders and metabolic changes of the embryos. The role of autophagy and hypoxia and their influence on apoptosis and thus regulation of embryonic invasion depth should also be further identified.

在该项目中，代表胚胎植入母体子宫内膜作为妊娠过程中的界面，应该进行检查。孕体侵入母体子宫内膜间质的深度至关重要。“浅植入”意义上的侵入过低，会导致妊娠期母婴发生危及生命的疾病。同样危险的是过度侵入，这可能导致胎盘脱落问题，可能导致分娩期间和分娩后危及生命的情况。一项研究表明，事实上，60%的妊娠早期和大多数未被发现的临床前阶段的妊娠没有正确发育。由于到目前为止还没有完全理解足够的胎盘形成和着床的操作，因此本文将研究调节确切侵入深度的细胞机制。因此，应该回答如何在母体组织中创建胚胎适当植入所需的空间以及如何正确调节侵入深度的问题。趋化因子受体Syndecan-1似乎在胚胎植入过程中发挥作用，特别是在介导细胞凋亡中。本文将阐明Syndecan-1利用哪些信号传导途径诱导细胞凋亡以及它如何调节孕体的侵入深度以促进适当的植入。此外，还应研究Syndecan-1表达失调是否会引起妊娠障碍和胚胎代谢变化。自噬和缺氧的作用及其对细胞凋亡的影响，从而调节胚胎的侵入深度也应该进一步确定。

项目成果

Are uterine natural killer and plasma cells in infertility patients associated with endometriosis, repeated implantation failure, or recurrent pregnancy loss?

• DOI: 10.1007/s00404-020-05679-z
• 发表时间: 2020-12
• 期刊: Archives of gynecology and obstetrics
• 影响因子: 2.6
• 作者: Freitag N;Pour SJ;Fehm TN;Toth B;Markert UR;Weber M;Togawa R;Kruessel JS;Baston-Buest DM;Bielfeld AP
• 通讯作者: Bielfeld AP

Physiological and anatomical aspects of the reproduction of mice with reduced Syndecan-1 expression

• DOI: 10.1186/s12958-019-0470-2
• 发表时间: 2019-03-02
• 期刊: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
• 影响因子: 4.4
• 作者: Gougoula, Christina;Bielfeld, Alexandra P.;Baston-Buest, Dunja M.
• 通讯作者: Baston-Buest, Dunja M.

Metabolic and behavioral parameters of mice with reduced expression of Syndecan-1

• DOI: 10.1371/journal.pone.0219604
• 发表时间: 2019-07-12
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Gougoula, Christina;Bielfeld, Alexandra Petra;Baston-Buest, Dunja Maria
• 通讯作者: Baston-Buest, Dunja Maria