Muscle stem cell quiescence and heterogeneity

卫星细胞是成体骨骼肌的干细胞，为肌肉再生提供细胞来源。虽然在出生后早期肌肉生长期间高度增殖，但卫星细胞在成人中变得静止。作为对损伤的反应，卫星细胞被激活并产生用于肌肉修复的成肌细胞，但亚群自我更新以形成新的静止干细胞。静止卫星细胞具有低代谢率和抗应激性。我们建议在这里加入法国和德国的团队，以确定分子机制，允许建立/维持静止的卫星细胞，包括人类卫星细胞，并在肌肉再生。此外，我们将表征卫星细胞的异质性，以定义尚未了解的具有高再生能力的弹性干细胞亚群。这一雄心勃勃且可行的项目是基于法国和德国合作伙伴的持续合作以及互补的专业知识。

Satellite cells, the stem cells of the adult skeletal muscle, provide the cellular source for muscle regeneration. While highly proliferative during early postnatal muscle growth, satellite cells become quiescent in the adult. In response to injury, satellite cells are activated and generate myoblasts for muscle repair, but a subpopulation self-renews to form new quiescent stem cells. Quiescent satellite cells have low metabolic rates and are stress resistant. We propose here to join efforts of French and German teams to identify the molecular mechanisms allowing the establishment/maintenance of quiescence in satellite cells, including human satellite cells, and during muscle regeneration. Furthermore, we will characterize satellite cell heterogeneity to define the as yet little understood resilient stem cell subpopulation that possesses high regenerative capacity. This ambitious and feasible project is based on ongoing collaborations as well as complementary expertise of French and German partners.