KFO 311: Cardiac and pulmonary failure: mechanical unloading andrepair

KFO 311：心肺衰竭：机械卸载和修复

• 批准号: 286251789
• 金额: --
• 依托单位: Institut für Pathologie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/286251789?language=en
• 关键词: KFO; 311; Cardiac; pulmonary; failure

The number of patients with advanced cardiac and pulmonary failure is constantly increasing. Their treatment requires clinical experience, interdisciplinary commitment, and, in many cases, the most advanced medical devices, including microaxial pumps, extracorporal membrane oxygenation (ECMO), and ventricular assist devices (VAD) - all very well established at Hannover Medical School (MHH). These intra- and extracorporal devices may transiently or permanently unload failing organs, replace organ function, prevent therapy-related adverse side effects, provide time for endogenous or exogenous repair, or represent an ultimate destination therapy for end-stage heart failure. However, these treatments are often not evidence-based and cost-intensive, and may be associated with severe complications. What is more, the mechanistic underpinnings of mechanical unloading and support in advanced cardiac and pulmonary failure are only incompletely understood. Thus, basic and translational research in this area is urgently needed and promises (i) insight into the biological effects of mechanical unloading in end-stage cardiac and pulmonary failure, (ii) discovery of novel biological and pharmacological therapies, (iii) identification of innovative applications and evidence-based development of future unloading and support strategies. Based on the outstanding scientific and clinical expertise of the participating MHH Departments and Institutes, this Clinical Research Unit (KFO) will explore the effects of mechanical unloading on local and systemic pathomechanisms in advanced cardiac and pulmonary failure to improve current and/or develop novel therapeutic strategies. In an early translational approach, novel approaches will be evaluated in preclinical and clinical trials. The KFO unites cardiovascular, pulmonary, surgical, and imaging expertise on a preclinical and clinical level. Preclinical and clinical trials will greatly benefit from established networks between clinical departments, highly-specialized institutes, and excellent core facilities at MHH. MHH is one of the leading University hospitals in Germany and a center for supramaximal care for patients with the most complex diseases. Basic and clinical research in advanced organ failure has been defined as one of the focus areas at MHH. In the long-term, this KFO initiative will strengthen the national and international role of MHH as a center of excellence in advanced cardiac and pulmonary failure.

晚期心肺衰竭患者的数量不断增加。他们的治疗需要临床经验，跨学科的承诺，并在许多情况下，最先进的医疗设备，包括微轴泵，体外膜氧合（ECMO），心室辅助装置（VAD）-所有在汉诺威医学院（MHH）非常完善。这些体内和体外装置可以暂时或永久地卸载衰竭器官、替代器官功能、预防治疗相关的不良副作用、为内源性或外源性修复提供时间，或者代表终末期心力衰竭的最终目的治疗。然而，这些治疗往往没有证据和成本密集型，并可能与严重的并发症。更重要的是，机械卸载和支持在先进的心脏和肺功能衰竭的机械基础只是不完全理解。因此，在这一领域的基础和转化研究是迫切需要的，并承诺（i）洞察机械卸载在终末期心脏和肺衰竭的生物学效应，（ii）发现新的生物和药理学疗法，（iii）识别创新应用和未来卸载和支持策略的循证发展。基于参与MHH部门和研究所的杰出科学和临床专业知识，该临床研究单位（KFO）将探索机械卸载对晚期心肺衰竭局部和全身病理机制的影响，以改善当前和/或开发新的治疗策略。在早期转化方法中，将在临床前和临床试验中评估新方法。KFO在临床前和临床水平上联合了心血管、肺、外科和成像专业知识。临床前和临床试验将极大地受益于MHH临床部门、高度专业化的研究所和卓越的核心设施之间建立的网络。MHH是德国领先的大学医院之一，也是为患有最复杂疾病的患者提供超大护理的中心。晚期器官衰竭的基础和临床研究已被定义为MHH的重点领域之一。从长远来看，这项KFO计划将加强MHH作为高级心脏和肺衰竭卓越中心的国家和国际作用。