ヒト疾患バイオマーカーの生体外単一分子検出の為の流体光学プラズモンプラットホーム

用于人类疾病生物标志物体外单分子检测的流体光学等离子体平台

• 批准号: 21F20789
• 负责人: 合田 圭介
• 金额: $ 1.47万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-07-28 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21F20789/
• 关键词: Wearable sensors; biosensing; Raman spectroscopy; gold nanoparticles; nanomesh; SERS

I published an perspectives paper in Europhysics Letters. We review the theory of metal-free SERS, including electromagnetic enhancement and chemical enhancement, and introduce promising substrates developed recently, including MXenes, transition metal dichalcogenides, and carbon-based substrates. Moreover, we clarify challenges, provide potential solutions, and discuss unexploited applications. This perspective provides not only a broad and detailed view of metal-free SERS at the current stage, but also a roadmap for its future advancement.I submitted a paper to Advanced Optical Materials that is currently under review. In this paper we demonstrate a highly scalable, wearable SERS sensor based on an easy-to-fabricate, low-cost, ultrathin, flexible, stretchable, adhesive, and bio-integratable gold nanomesh. It can be fabricated in any shape and worn on virtually any surface for label-free, large-scale, in-situ sensing of diverse analytes from low to high concentrations. To show the practical utility of the wearable SERS sensor, we test the sensor for the detection of sweat biomarkers, drugs of abuse, and microplastics. This wearable SERS sensor represents a significant step toward the generalizability and practicality of wearable sensing technology.I presented my early results at the EUROPEAN RESEARCH DAYS - European Researchers in Japan: Achievements and Opportunities as an invited speaker and some more generic concepts at the Tokyo Metropolitan High School of Science and Technology under the JSPS Science Dialogue initiative to disseminate science.

我在《欧洲物理快报》上发表了一篇观点论文。本文综述了无金属SERS的理论，包括电磁增强和化学增强，并介绍了近年来发展起来的有前途的衬底，包括MXenes、过渡金属二硫族化合物和碳基衬底。此外，我们阐明了挑战，提供了潜在的解决方案，并讨论了未开发的应用程序。这一视角不仅提供了现阶段无金属SERS的广泛而详细的视图，而且为其未来的发展提供了路线图。我向Advanced Optical Materials提交了一篇论文，目前正在审核中。在本文中，我们展示了一种高度可扩展、可穿戴的SERS传感器，该传感器基于易于制造、低成本、超薄、柔性、可拉伸、可粘合和生物可集成的金纳米网。它可以制造成任何形状，几乎可以在任何表面上使用，用于无标签，大规模，从低到高浓度的各种分析物的原位传感。为了展示可穿戴SERS传感器的实际用途，我们测试了传感器用于检测汗液生物标志物，滥用药物和微塑料。这种可穿戴SERS传感器代表了可穿戴传感技术的通用性和实用性的重要一步。我在“欧洲研究日-欧洲研究人员在日本：成就与机遇”会议上作为特邀演讲者介绍了我的早期研究成果，并在JSPS科学对话倡议下在东京都科学技术高中介绍了一些更一般的概念，以传播科学。

项目成果

Metal-free SERS: Where we are now, where we are heading

无金属 SERS：我们现在的处境，我们的前进方向

• DOI: 10.1209/0295-5075/ac4d40
• 发表时间: 2021
• 期刊: Europhysics Letters
• 作者: Martinez Pancorbo Pablo;Zhang Huanhuan;Yu Xingxing;Xiao Ting-Hui;Goda Keisuke
• 通讯作者: Goda Keisuke

Nanomaterials for biosensing and medical diagnosis

用于生物传感和医学诊断的纳米材料

• 发表时间: 2021
• 作者: de Bernardi;Cecilia;Edelheim;Johan;& Crossley;Emilie;Fabian Eisenstein;Pablo Martinez Pancorbo,
• 通讯作者: Pablo Martinez Pancorbo,