Molecular imaging and modulation of fibrosis and inflammation incardiac pressure overload and relief

心脏压力超负荷和缓解中纤维化和炎症的分子成像和调节

• 批准号: 317748256
• 负责人: Professor Dr. Frank Bengel
• 金额: --
• 依托单位: Klinik für Nuklearmedizin
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/317748256?language=en
• 关键词: Molecular; imaging; modulation; fibrosis; inflammation

In project 10, quantitative imaging assays based on magneticresonance imaging (MRI) and positron emission tomography (PET)will be combined for noninvasive detection of biological changes inthe heart in response to cardiac pressure overload and relief. Inaddition, crosstalk with other organs and systems will be investigatedby whole-body imaging. The multimodal approach will facilitate an indepth characterization of various aspects of inflammation and fibrosis,along with their changes over time. Imaging will also be used to guidetargeted molecular therapies and to determine the success oftreatment (“image-guided therapy”). The hypotheses generated inexperimental animals will be cross-validated in human tissue samples from failing hearts, which will serve to provide the basis for successfulclinical translation. Owing to the broad feasibility of multimodalimaging in animal models and clinical settings, along with applicabilityto multiple organs, this project will tightly network with many projectsof the clinical research group in order to facilitate their success.

在项目10中，基于磁共振成像(MRI)和正电子发射断层扫描(PET)的定量成像分析将被结合起来，以非侵入性检测心脏内响应心脏压力超负荷和缓解的生物变化。此外，与其他器官和系统的串扰将通过全身成像进行研究。多模式方法将有助于深入描述炎症和纤维化的各个方面，以及它们随时间的变化。成像还将用于指导靶向分子治疗和确定治疗的成功(“图像引导治疗”)。在实验动物中产生的假说将在人体衰竭心脏组织样本中交叉验证，这将为成功的临床移植提供基础。由于多模式成像在动物模型和临床环境中的广泛可行性，以及对多个器官的应用，该项目将与临床研究小组的许多项目紧密联系，以促进其成功。