Ameliorating Cognitive Control in Binge Eating Disorder by Electrical Brain Stimulation (ACCElect)

通过脑电刺激改善暴食症的认知控制 (ACCElect)

• 批准号: 318604969
• 负责人: Professorin Dr. Katrin Giel
• 金额: --
• 依托单位: Abteilung Allgemeine Psychiatrie und Psychotherapie mit Poliklinik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/318604969?language=en
• 关键词: Ameliorating; Cognitive; Control; Binge; Eating

Patients with BED form a subgroup of obese patients with a disinhibited eating pattern that is associated with major impairments in cognitive control. The dlPFC has been identified as a brain region closely tied to cognitive control processes and crucially involved in the control of eating behaviour. This suggests the dlPFC as a target for the modulation of cognitive control processes over eating in BED. This modulation can be achieved by both, a cognitive training task and by non-invasive brain stimulation using tDCS. In studies with healthy normal-weight participants, (1) different cognitive training task enhance control over eating behaviour, (2) tDCS is an effective tool to ameliorate cognitive control processes, and (3) has beneficial effects on motivational aspects of eating behaviour, i.e. food craving. Based on this evidence, we will use a combination of a cognitive control task and tDCS to enhance cognitive control over eating in patients with BED. This is to the best of our knowledge the first study to use non-invasive brain stimulation in BED patients and one of the first studies to use tDCS as an intervention to enhance cognitive control over eating.

BED患者是肥胖患者的一个亚组，其饮食失调模式与认知控制的主要障碍有关。dlPFC被认为是一个与认知控制过程密切相关的大脑区域，对饮食行为的控制至关重要。这表明dlPFC是BED中饮食认知控制过程调节的目标。这种调节可以通过认知训练任务和使用tDCS的非侵入性脑刺激来实现。在健康体重正常的被试中，(1)不同的认知训练任务增强了对饮食行为的控制，(2)tDCS是改善认知控制过程的有效工具，(3)对饮食行为的动机方面（即食物渴望）有有益的影响。基于这一证据，我们将使用认知控制任务和tDCS相结合的方法来增强BED患者对饮食的认知控制。据我们所知，这是第一个在BED患者中使用非侵入性脑刺激的研究，也是第一个使用tDCS作为干预手段来增强对饮食的认知控制的研究之一。

项目成果

Nicht-invasive Hirnstimulation als Behandlungsverfahren bei Essstörungen – ein narrativer Überblick

非侵入性脑刺激治疗饮食失调 - 叙述概述

• DOI: 10.1055/a-1156-8899
• 发表时间: 2020
• 期刊: PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie
• 作者: Zipfel;Plewnia
• 通讯作者: Plewnia