"ADHD MoveS": Genetics of Attention Deficit Hyperactivity Disorder (ADHD): Analysis of Mendelian subtypes

“ADHD MoveS”：注意力缺陷多动障碍（ADHD）的遗传学：孟德尔亚型分析

• 批准号: 320398808
• 负责人: Dr. Andrea Schote-Frese
• 金额: --
• 依托单位: Abteilung für Verhaltensgenetik
• 依托单位国家: 德国
• 项目类别: Scientific Networks
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/320398808?language=en
• 关键词: ADHD; MoveS; Genetics; Attention; Deficit

Attention deficit hyperactivity disorder (ADHD) is researched intensively for many years by large international consortia and is subject to the so-called "complex inheritance", which means that many genetic variants and environmental factors interact in the pathogenesis. A special case is the monogenic inherited form of ADHD. "Mendelian" inheritance means that over several generations a strong family history of a phenotype can be observed. In this case, the causative gene can be identified by a linkage analysis. Few studies deal with this type of ADHD, including publications of the working group of the applicant. As members of the scientific network "ADHD MoveS", young researchers especially from the fields of medicine and psychology should be sensitized for the presence of these monogenic subtypes of complex disorders. In addition, the young researchers should be trained with respect to the recruitment of large pedigrees, the opportunities of defining endophenotypes and the genotyping in the context of linkage analysis for these subtypes. Goals of the network are the publication of a review article with the topic "Monogenic subtypes of complex disorders in research and practice" and the preparation of a DFG grand proposal.

注意力缺陷多动障碍（ADHD）是国际大型财团多年来研究的热点，其发病机制是复杂遗传，即多种遗传变异与环境因素相互作用。一个特殊的情况是单基因遗传形式的ADHD。“孟德尔”遗传意味着在几代人中可以观察到表型的强烈家族史。在这种情况下，可以通过连锁分析来鉴定致病基因。很少有研究涉及这种类型的ADHD，包括申请人工作组的出版物。作为科学网络“ADHD MoveS”的成员，年轻的研究人员，特别是来自医学和心理学领域的研究人员，应该对这些复杂疾病的单基因亚型的存在保持敏感。此外，年轻的研究人员应在招募大谱系，确定内表型的机会和这些亚型的连锁分析背景下的基因分型方面进行培训。该网络的目标是发表一篇题为“研究和实践中复杂疾病的单基因亚型”的综述文章，并准备DFG的重大提案。

项目成果

Stress and impulsivity: The effects of the variant BclI (rs41423247) of the glucocorticoid receptor gene on impulsivity action and impulsivity choice

压力与冲动：糖皮质激素受体基因变异体 BclI (rs41423247) 对冲动行为和冲动选择的影响

• DOI: 10.1016/j.psyneuen.2019.07.033
• 发表时间: 2019
• 期刊: Psychoneuroendocrinology
• 影响因子: 3.7
• 作者: Andrea B Schote;Clara Sayk;Ulrike Winnikes;Matthias Vonmoos;Lea M. Hulka;Katrin H. Preller;Boris Quednow;Jobst Meyer
• 通讯作者: Jobst Meyer