"ADHD MoveS": Genetics of Attention Deficit Hyperactivity Disorder (ADHD): Analysis of Mendelian subtypes

注意缺陷多动障碍（ADHD, Attention deficit hyperactivity disorder，简称ADHD）是国际大型财团多年来对其进行深入研究的一种疾病，属于所谓的“复杂遗传”，即多种遗传变异和环境因素在其发病机制中相互作用。一个特殊的例子是单基因遗传性多动症。“孟德尔”遗传意味着在几代人的时间里，可以观察到一种表型的强烈家族史。在这种情况下，可以通过连锁分析确定致病基因。很少有研究涉及这种类型的多动症，包括申请人工作组的出版物。作为“多动症运动”科学网络的成员，年轻的研究人员，特别是来自医学和心理学领域的研究人员，应该对这些复杂疾病的单基因亚型的存在保持敏感。此外，年轻的研究人员应该在招募大型谱系、定义内部表型的机会以及在这些亚型的连锁分析背景下进行基因分型方面进行培训。该网络的目标是发表一篇题为“研究和实践中复杂疾病的单基因亚型”的综述文章，并准备一份DFG宏伟提案。

Attention deficit hyperactivity disorder (ADHD) is researched intensively for many years by large international consortia and is subject to the so-called "complex inheritance", which means that many genetic variants and environmental factors interact in the pathogenesis. A special case is the monogenic inherited form of ADHD. "Mendelian" inheritance means that over several generations a strong family history of a phenotype can be observed. In this case, the causative gene can be identified by a linkage analysis. Few studies deal with this type of ADHD, including publications of the working group of the applicant. As members of the scientific network "ADHD MoveS", young researchers especially from the fields of medicine and psychology should be sensitized for the presence of these monogenic subtypes of complex disorders. In addition, the young researchers should be trained with respect to the recruitment of large pedigrees, the opportunities of defining endophenotypes and the genotyping in the context of linkage analysis for these subtypes. Goals of the network are the publication of a review article with the topic "Monogenic subtypes of complex disorders in research and practice" and the preparation of a DFG grand proposal.