Venomics: Molecular and functional analysis of Australian snake venoms for development of human therapeutics

毒液组学：澳大利亚蛇毒的分子和功能分析，用于开发人类疗法

• 批准号: LP0454264
• 负责人: Prof Martin Lavin
• 金额: $ 61.84万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-06-24 至 2007-06-24
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0454264
• 关键词: Venomics; Molecular; functional; analysis; Australian

Australian snake venoms are lethal cocktails with potent effects on mammalian physiological processes, designed to immobilize and kill prey animals. Major targets of venom components are the nervous and blood coagulation systems but there is reason to believe that venoms have many other as yet unrecognized effects on mammalian systems. The project will combine techniques of modern molecular biology (particularly transcriptomics and proteomics) with functional and structural analysis of purified venom components. Venoms from approximately 20 Australian snakes will be studied to reveal lead compounds for improved human pharmaceuticals against common disorders such as high blood pressure, bleeding and stroke.

澳大利亚蛇毒是一种致命的鸡尾酒，对哺乳动物的生理过程有强烈的影响，旨在杀死猎物。 毒液成分的主要目标是神经和血液凝固系统，但有理由相信毒液对哺乳动物系统有许多其他尚未认识到的影响。 该项目将把现代分子生物学（特别是转录组学和蛋白质组学）的联合收割机技术与纯化毒液成分的功能和结构分析结合起来。 研究人员将对大约20种澳大利亚蛇的毒液进行研究，以揭示用于改善人类药物的主要化合物，以治疗高血压、出血和中风等常见疾病。