Basic research of the significance of clock gene DEC1 decreases in chronic kidney disease progression

时钟基因DEC1降低在慢性肾病进展中意义的基础研究

• 批准号: 19K08710
• 负责人: Sato Fuyuki
• 金额: $ 2.83万
• 依托单位: Shizuoka Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K08710/
• 关键词: 時計遺伝子; 慢性腎不全; DEC1; 免疫染色; DEC2; CKD; 慢性腎疾患; 日内リズム

项目成果

A deficiency of Dec2 triggers periodontal inflammation and pyroptosis

Dec2 缺乏会引发牙周炎症和焦亡

• DOI: 10.1111/jre.12849
• 发表时间: 2021
• 期刊: Journal of Periodontal Research
• 影响因子: 3.5
• 作者: Oka S;Li X;Sato F;Zhang F;Tewari N;Kim IS;Zhong L;Hamada N;Makishima M;Liu Y;Bhawal UK
• 通讯作者: Bhawal UK

Differential expression of claudin-4, occludin, SOX2 and proliferating cell nuclear antigen between basaloid squamous cell carcinoma and squamous cell carcinoma

基底样鳞状细胞癌与鳞状细胞癌中claudin-4、occludin、SOX2及增殖细胞核抗原的差异表达

• DOI: 10.3892/mmr.2019.10417
• 发表时间: 2019
• 期刊: Mol Med Rep
• 影响因子: 3.4
• 作者: Sato F;Bhawal UK;Tojyo I;Fujita S;Murata SI;Muragaki Y
• 通讯作者: Muragaki Y

Smad3 Suppresses Epithelial Cell Migration and Proliferation via the Clock Gene Dec1, Which Negatively Regulates the Expression of Clock Genes Dec2 and Per1

• DOI: 10.1016/j.ajpath.2019.01.006
• 发表时间: 2019-04-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Sato, Fuyuki;Otsuka, Tsuyoshi;Muragaki, Yasuteru
• 通讯作者: Muragaki, Yasuteru

Potential role of DEC1 in cervical cancer cells involving overexpression and apoptosis

DEC1在宫颈癌细胞过度表达和凋亡中的潜在作用

• DOI: 10.3390/clockssleep2010004
• 发表时间: 2020
• 期刊: Clocks & Sleep
• 影响因子: 3.1
• 作者: Sato F;Bhawal UK;Sugiyama N;Osaki S;Oikawa K;Muragaki Y
• 通讯作者: Muragaki Y

Dec1 deficiency inhibits TAC-induced fibrosis in cardiac hypertrophy

Dec1 缺乏抑制 TAC 诱导的心脏肥大纤维化

• 发表时间: 2019
• 作者: Hue Thi Le;Fuyuki Sato;Akira Kohsaka;Ujial K Bhawal;Tomomi Nakao; Yasuteru Muragaki;Masanori Nakata.
• 通讯作者: Masanori Nakata.