Effect of a novel immobilised antimicrobial peptide on bacteria

新型固定化抗菌肽对细菌的作用

• 批准号: DP160101664
• 负责人: Prof Mark Willcox
• 金额: $ 27.51万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160101664
• 关键词: Effect; novel; immobilised; antimicrobial; peptide

This project plans to investigate a novel cationic peptide that prevents microbial colonisation of surfaces. The ability of bacteria to colonise surfaces affects almost all aspects of human life – from water to food and medical devices. As microbes become increasingly resistant to traditional biocides, the design of effective antimicrobial surfaces to prevent microbial colonisation and biofilm formation is critically important. The novel cationic peptide may provide a solution, but the mechanism of action of surface-bound peptides on bacteria is poorly understood. This project aims to combine biophysics, biochemistry, microbiology and molecular biology to study interactions with the surface of two model bacteria. This may facilitate optimal design of new coatings.

该项目计划研究一种新型阳离子肽，可以防止微生物在表面定植。细菌在表面定居的能力影响着人类生活的几乎所有方面——从水到食物和医疗设备。随着微生物对传统杀菌剂的抵抗力越来越强，设计有效的抗菌表面以防止微生物定植和生物膜的形成至关重要。新型阳离子肽可能提供了一种解决方案，但表面结合肽对细菌的作用机制尚不清楚。本项目旨在结合生物物理学、生物化学、微生物学和分子生物学，研究与两种模式细菌表面的相互作用。这可能有助于新涂料的优化设计。