The development of novel, biofilm-resistant biomaterials

新型抗生物膜生物材料的开发

• 批准号: nhmrc : 300586
• 负责人: Prof Mark Willcox
• 金额: $ 9.83万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-novel-biofilm-resistant-biomaterials/82502
• 关键词: development; novel; biofilm; resistant; biomaterials

Almost all patients who are catheterised long term develop a bacterial infection. Most often, the infection is the result of colonisation of the catheter surface by bacteria. Bacterial colonisation of the surface of biomedical devices represents a significant health threat as such bacterial biofilms are extremely resistant to traditional antibiotic regimens. This project aims to develop novel materials that prevent bacterial colonisation on catheters and other biomedical related devices. Our technology is based on compounds identified from a marine alga that prevent bacterial colonisation of its surface. Similarly, we have shown that these compounds, when coated onto test surfaces, prevent bacterial colonisation of a range of materials.

几乎所有长期留置导管的患者都会发生细菌感染。大多数情况下，感染是细菌在导管表面定植的结果。生物医学装置表面的细菌定殖代表了显著的健康威胁，因为这种细菌生物膜对传统抗生素方案具有极强的抗性。该项目旨在开发新型材料，以防止导管和其他生物医学相关设备上的细菌定植。我们的技术基于从海洋生物中鉴定出的化合物，可以防止细菌在其表面定植。同样，我们已经证明，当这些化合物涂覆在测试表面上时，可以防止一系列材料的细菌定植。