Examination of unique tear lipids and their role in the tear film's structure and function.

检查独特的泪液脂质及其在泪膜结构和功能中的作用。

• 批准号: LP140100711
• 负责人: Prof Mark Willcox
• 金额: $ 31.72万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-06-30 至 2019-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140100711
• 关键词: Examination; unique; tear; lipids; their

The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is significant because the unique combination of skills including synthetic chemistry, mass spectrometry, lipidomics, biochemistry, biophysics which aim to result in a major shift in the understanding of this layer.

泪膜脂质层覆盖眼睛，稳定眼泪并防止它们蒸发。然而，其结构、功能和组成尚未完全阐明。该项目的目的是充分研究这一层中的独特脂质，即长链ω-羟基脂肪酸（在身体其他地方没有发现），并确定它们在其结构和功能中的作用。该项目意义重大，因为独特的技能组合，包括合成化学，质谱，脂质组学，生物化学，生物物理学，旨在导致对这一层的理解发生重大转变。