Development of atom-economical and stereoselective catalytic radical reactions

原子经济和立体选择性催化自由基反应的发展

• 批准号: 377331858
• 负责人: Professor Dr. Andreas Gansäuer
• 金额: --
• 依托单位: Kekulé-Institut für Organische Chemie und Biochemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/377331858?language=en
• 关键词: Development; atom; economical; stereoselective; catalytic

Catalysis is an enabling branch of science providing access to novel materials and processes. It is therefore ideally suited to deliver sustainable solutions for the demands of modern societies. As pointed out by Anastas[1] this is so, because catalysis can be employed in the design of selective processes that maximize the amount of raw material ending up in the product, in the use of renewable energy sources and in avoiding the production of waste. We have demonstrated that radicals are attractive as key-intermediates for sustainable catalysis by developing systems for radical reduction or arylation through the coupling of catalytic cycles and for epoxide hydrosilylations. These results lead the way for a mechanism-guided design of efficient catalysts for new and highly stereoselective as well as sustainable radical reactions.

催化是一门能够提供获得新材料和新工艺的科学分支。因此，它非常适合为现代社会的需求提供可持续的解决方案。正如阿纳斯塔斯[1]所指出的，这是因为催化可以用于选择性工艺的设计，以最大限度地增加最终进入产品的原材料的数量，使用可再生能源，并避免产生废物。我们已经证明了自由基作为可持续催化的关键中间体是有吸引力的，通过开发通过催化循环耦合的自由基还原或芳基化和环氧化物硅氢化反应的系统。这些结果为以机理为导向的新型、高立体选择性和可持续自由基反应的高效催化剂的设计提供了方向。