Development of atom-economical multicomponent coupling reactions via hypervalent ate complexes

我们已经开发了多组分的偶联反应，其中来自芳烃的两性离子和中性亲核试剂被炔基或全氟芳基溴化物捕获。这些反应通过形成由有机溴化物的两性离子的芳基阴离子部分和溴部分生成的高价酸根络合物来进行。异氰化物和环醚(四氢呋喃、氧杂环烷)在反应中可作为中性亲核剂。此外，还利用氧杂环己烷衍生产物实现了生物活性分子的全合成。

We have developed multicomponent coupling reactions, where zwitterions derived from arynes and neutral nucleophiles are trapped by alkynyl or perfluoroaryl bromides. These reactions proceed through formation of hypervalent ate complexes generated from aryl anion moieties of the zwitterions and bromine moieties of the organic bromides. Isocyanides and cyclic ethers (THF, oxetane) can serve as neutral nucleophiles in the reaction. Furthermore, total synthesis of a biologically active molecule has been achieved by using the oxetane-derived product.