Impact of host genetic variation and environmental influences on the cutaneous microbiome composition

宿主遗传变异和环境影响对皮肤微生物组组成的影响

• 批准号: 387771232
• 负责人: Professor Dr. Stephan Weidinger
• 金额: --
• 依托单位: Institut für Klinische Molekularbiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/387771232?language=en
• 关键词: Impact; host; genetic; variation; environmental

The composition of the skin microbiome likely contributes to a wide-range of health and disease states including chronic inflammatory skin diseases. It is shaped by both environmental and host (genetic) components. In contrast to the large-scale efforts of the Human Microbiome Project to catalogue the healthy cutaneous microbial flora at different body sites, relatively little has been accomplished to characterize the host and environmental factors impacting the skin microbiome. To date, there are no genome-wide studies that have attempted to characterize specific genes and pathways in the human genome that may shape the composition of the skin microbiome, and relatively little is known on the impact of specific extrinsic individual-dependent factors such as UV-exposure, pet exposure and dietary habits. Finally, potential correlations between the microbiome composition at the skin and other body sites have not been examined so far. The proposed project therefore aims at comprehensively profiling the impact of human genetic variation and selected environmental factors on the composition of the cutananeous microbial ecosystem at 3 sites on a genome- and microbiome-wide scale, and to examine the concordance of skin and gut microbiomes, in two well characterized population-based cohorts comprising 386 (KORA) and 600 (POPGEN) adults.

皮肤微生物群的组成可能对包括慢性炎症性皮肤病在内的一系列健康和疾病状态做出贡献。它是由环境和宿主(遗传)成分共同决定的。与人类微生物组计划大规模地对不同身体部位的健康皮肤微生物区系进行分类相比，对影响皮肤微生物组的宿主和环境因素的表征相对较少。到目前为止，还没有全基因组的研究试图描述人类基因组中可能塑造皮肤微生物组组成的特定基因和途径，对于特定的外部个体依赖因素的影响，如紫外线暴露、宠物暴露和饮食习惯，人们知之甚少。最后，到目前为止，还没有研究皮肤和其他身体部位微生物群组成之间的潜在相关性。因此，拟议的项目旨在在基因组和微生物组范围内全面分析人类遗传变异和选定的环境因素对3个地点皮肤微生物生态系统组成的影响，并在包括386名(KORA)和600名(POPGEN)成年人的两个特征良好的人群队列中检查皮肤和肠道微生物群的一致性。

项目成果

Host traits, lifestyle and environment are associated with human skin bacteria

宿主特征、生活方式和环境与人类皮肤细菌有关

• DOI: 10.1111/bjd.20072
• 发表时间: 2021
• 期刊: British Journal of Dermatology
• 影响因子: 10.3
• 作者: Moitinho-Silva L;Boraczynski N;Emmert H;Baurecht H;Szymczak S;Schulz H;Haller D;Linseisen J;Gieger C;Peters A;Tittmann L;Lieb W;Bang C;Franke A;Rodriguez E;Weidinger S
• 通讯作者: Weidinger S