Coordination

协调

• 批准号: 393033969
• 负责人: Professor Dr. Axel Roers
• 金额: --
• 依托单位: Institut für Immunologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/393033969?language=en
• 关键词: Coordination

Microbial and non-infectious insults trigger distinct inflammatory response patterns that fundamentally differ, dependent on the stimulus and the affected tissue. The choice of the right quality of immune response determines whether it will be efficient and beneficial or, on the contrary, cause additional damage. Type 2 immunity designates the response pattern activated by helminth infection, allergens and venoms, but also during the repair process in wounded tissue. It is defined by a dominant milieu of the cytokines IL-4, IL-5 and IL- 13. The term “type 2 response” embraces both the ‘innate’ type 2 responses of tissues and the subsequent adaptive TH2 and IgE responses, the latter being instructed by the initial innate response. While type 2 immunity serves key functions in defense, tissue repair and metabolic regulation, and is the driver of allergic and fibrotic disease, factors controlling type 2 responses are still unclear. We aim to elucidate the fundamental mechanisms that induce and regulate type 2 immunity in normal tissues, and in pathologies where type 2 immunity is required for protection, or is a promoter of disease. FOR2599 integrates leading experts in the biology of important cell types that contribute to type 2 responses, including M2 macrophages, innate lymphoid cells, dendritic cells, eosinophilic and basophilic granulocytes and mast cells. The group combines expertise in key signaling pathways regulating type 2 responses and has available a unique spectrum of innovative genetic mouse lines and in vivo disease models. This enables tremendous synergy, putting FOR2599 in an ideal position to elucidate how the various tissue cells interact to mount and regulate a local type 2 response in steady state or under conditions of tissue stress of different nature and intensity.

微生物和非感染性损伤触发不同的炎症反应模式，这些模式从根本上不同，取决于刺激和受影响的组织。选择正确的免疫反应质量决定了它是否有效和有益，或者相反，造成额外的损害。2型免疫指的是由蠕虫感染、过敏原和毒液激活的反应模式，但也指在受伤组织的修复过程中的反应模式。它由细胞因子IL-4、IL-5和IL- 13的优势环境定义。术语“2型应答”包括组织的“先天”2型应答和随后的适应性TH 2和IgE应答，后者由初始先天应答指示。虽然2型免疫在防御，组织修复和代谢调节中发挥关键作用，并且是过敏和纤维化疾病的驱动因素，但控制2型反应的因素仍不清楚。我们的目标是阐明诱导和调节2型免疫在正常组织中的基本机制，以及在病理学中，2型免疫是保护所必需的，或者是疾病的促进剂。FOR 2599整合了有助于2型反应的重要细胞类型的生物学方面的领先专家，包括M2巨噬细胞，先天性淋巴细胞，树突状细胞，嗜酸性和嗜碱性粒细胞和肥大细胞。该小组结合了调节2型反应的关键信号通路的专业知识，并提供了独特的创新遗传小鼠品系和体内疾病模型。这使得巨大的协同作用，使FOR 2599处于理想的位置，以阐明各种组织细胞如何相互作用，以在稳态或不同性质和强度的组织应力条件下建立和调节局部2型反应。