Study of Environmentally Benign One-Pot Syntheses of Heterocyclic Key Intermediates for Drug

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We studied one-pot syntheses of imidazoles, thiazoles and oxazoles from styrenes; however, we could not obtain the corresponding heterocyclic compounds. Since considerable quantity of intermediates phenacyl halides were detected in the reaction mixture, deactivation of coupling reagents, for example thioamides, is thought to be the reason for these results. We believe that further optimization of reaction conditions for activation of coupling reagent develops one-pot synthesis of these heterocyclic compounds.