Acceleration of colitis in vitamin A deficiency: Demonstrationby experimental mouse model

点击翻译按钮获取中文摘要

To see the influence of vitamin A deficiency on colitis, Dextran sulfate sodium-colitis was induced in vitamin A deficient and vitamin A-supplemented mice. Colitis was significantly severer in vitamin A deficient mice than vitamin A-supplemented mice. cDNA microarray analysis showed different gene expression between two groups, suggesting some relation to acceleration of colitis. Thus, it is demonstrated that vitamin A supplement might improve chronic diarrhea or colitis in low nutrient infants.