Insufficient crosstalk between epithelium and stroma in chronic inflammation-carcinoma sequence: Analysis of a disease model
Insufficient crosstalk between epithelium and stroma in chronic inflammation-carcinoma sequence: Analysis of a disease model
批准号:
20590353
负责人:
OKAYASU Isao
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
As organ-specific chronic inflammation-carcinoma sequence, we have analyzed ulcerative colitis (UC)-colorectal carcinoma system, and shown alterations of crosstalk between mucosal crypt epithelia and stromal cells, with decrease of subepithelial myofibroblasts and acceleration of genomic instability of interstitial cells, as well as mucosal remodeling, relating to tumorigenesis.
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Correlation among total colonoscopic findings, clinical Symptoms, and laboratory markers in ulcerative colitis.
溃疡性结肠炎的总结肠镜检查结果、临床症状和实验室标志物之间的相关性。
DOI:
--
发表时间:
2008
期刊:
J Gastroenterol Hepatol Suppl 2
影响因子:
--
作者:
[Osada T, Ohkusa T, Oka-yasu I, Yoshida T, et al]
通讯作者:
et al
DOI:
10.1038/sj.bjc.6605163
发表时间:
2009-08-04
期刊:
BRITISH JOURNAL OF CANCER
影响因子:
8.8
作者:
[Araki, K., Mikami, T., Yoshida, T., Kikuchi, M., Sato, Y., Oh-ishi, M., Kodera, Y., Maeda, T., Okayasu, I.]
通讯作者:
Okayasu, I.
Significance of gene expression and localization in active and inactive ulcerative colitis by comprehensive analysis
综合分析活动性和非活动性溃疡性结肠炎基因表达和定位的意义
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Miyamae Y, Yoshida T, Okayasu I.]
通讯作者:
Okayasu I.
CITED2 is activated ulcerative colitis and induces p53-dependent apoptosis in response to butyric acid
CITED2 是激活的溃疡性结肠炎,并诱导 p53 依赖性细胞凋亡以响应丁酸
DOI:
--
发表时间:
2010
期刊:
J Gastroenterol
影响因子:
6.3
作者:
[Yoshida T, 他4名, Okayasu I.]
通讯作者:
Okayasu I.
DOI:
10.1080/00365520902718705
发表时间:
2009-01-01
期刊:
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
影响因子:
1.9
作者:
[Shiraishi, Hiroaki, Mikami, Tetuo, Takubo, Kaiyo]
通讯作者:
Takubo, Kaiyo
共 16 条
An Evaluation Study of Community Development through Sports Event
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批准号:25750319
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$0.67万
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财政年份:2013
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负责人:OKAYASU Isao
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依托单位:
A study on continuous participation in sport events applying the concept of specialization
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批准号:23700735
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$0.58万
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财政年份:2011
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负责人:OKAYASU Isao
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依托单位:
Acceleration of colitis in vitamin A deficiency: Demonstrationby experimental mouse model
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批准号:23659190
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:OKAYASU Isao
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依托单位:
Genetic instability of stromal cells in ulcerative colitis-associated carcinogenesis
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批准号:14570160
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2002
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负责人:OKAYASU Isao
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依托单位:
Promotion effect of lymchocytic thyroiditis in thyroid carcinogenesis by activation of RET protoncogene
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批准号:11670189
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1999
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负责人:OKAYASU Isao
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依托单位:
The role of telomerase activity in thyroid tumorigenesis
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批准号:09670202
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1997
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负责人:OKAYASU Isao
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依托单位:
The Role of age on induction and continuity of autoimmune thyroiditis
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批准号:63570153
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1988
-
负责人:OKAYASU Isao
-
依托单位:
海外基金