Development of new technology for the analysis of and pharmacological effects on intracellular and intercellular conduction, using pulse-driven MI sensor operated at room temperature

使用室温下操作的脉冲驱动 MI 传感器开发用于分析细胞内和细胞间传导及其药理作用的新技术

• 批准号: 23659397
• 负责人: NAKAYAMA Shinsuke
• 金额: $ 2.41万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659397/
• 关键词: 磁気センサー; 非侵襲; 上部消化管; ペースメーカー電流; 再生医療; ペースメーカ電流; 再生医療応用

Magnetic sensors constructed with a magnetic amorphous wire surrounded by a pickup-coil, are referred to as MI sensor. In this study, a pair of MI magnetic sensors were operated by applying electric current through a CMOS inverter circuit, and were used as a gradio-sensor by using a differential amplifier circuit. During musculature preparations isolated from the gut of animals were superfused with an extracellular solution, and spontaneous magnetic waves were successfully recorded. In some experiments, electric field potentials were simultaneously recorded by suing extracellular electrodes along with magnetic waves.

磁传感器是由由拾取线圈包围的磁性非晶导线构成的，称为MI传感器。在本研究中，一对MI磁传感器通过CMOS逆变电路施加电流来工作，并通过差分放大电路作为梯度传感器。从动物肠道中分离的肌肉组织制剂与细胞外溶液混合，成功地记录了自发电磁波。在一些实验中，用细胞外电极和电磁波同时记录电场电位。

项目成果

Orexins stimulate the 'appetite' of the gut.

食欲素刺激肠道的“食欲”。

• 发表时间: 2011
• 期刊: Journal of Physiology
• 作者: 西川尚子;富谷智明;大友夏子;井上有希子;池田均;白瀧博通;小池和彦;Nakayama S
• 通讯作者: Nakayama S

Pulse-Driven Magnetoimpedance Sensor Detection of Cardiac Magnetic Activity

• DOI: 10.1371/journal.pone.0025834
• 发表时间: 2011-10-12
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Nakayama, Shinsuke;Sawamura, Kenta;Uchiyama, Tsuyoshi
• 通讯作者: Uchiyama, Tsuyoshi

Cooperative gut motility requires the network of pacemaker cells

肠道协同运动需要起搏细胞网络

• 发表时间: 2013
• 作者: 中山晋介;谷口 瑞樹;Habibul B. Shozib
• 通讯作者: Habibul B. Shozib

磁気検出装置

磁性检测装置

• 发表时间: 2012

Pulse-driven magnetoimpedance sensor detection of biomagnetic fields in musculatures with spontaneous electric activity

• DOI: 10.1016/j.bios.2011.05.041
• 发表时间: 2011-09-15
• 期刊: BIOSENSORS & BIOELECTRONICS
• 影响因子: 12.6
• 作者: Nakayama, Shinsuke;Atsuta, Satoshi;Uchiyama, Tsuyoshi
• 通讯作者: Uchiyama, Tsuyoshi