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Physiological Relevance ofIntracellular Magnesium

细胞内镁的生理相关性

基本信息

批准号：
10044263
负责人：
NAKAYAMA Shinsuke
金额：
$ 1.47万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

During the tenure of the international collaboration grants from Monbusho and JSPS, shinsuke Nakayama (Head Investigator) four times visited Oxford University. S. Nakayama worked together with Alison F. Brading, Joseph F. Clark, Lorraine M. Smith and Shun-ichi Kajioka, and examined the effects of Mg^<2+> on membrane currents in isolated smooth muscle cells. On this electrophysiological study, one paper has been published. Also, during Nakayama was staying in Oxford, L.M. Smith provided many useful comments on a manuscript describing about the interaction of sympathomimetic and parasympathomimetic drugs on intracellular Mg^<2+> concentration ([Mg^<2+>]_j) in heart. This paper has also appeared in s scientific journal.On the other hand, in Japan end, Tatsu-aki Matsubara, Tetsuya Amano, Hideki Nomura and S. Nakayama examined various hormonal effects on intracellular Mg2+ regulation in heart and blood vessels using nuclear magnetic resonance. A novel finding in this NMR study is that insul … More in antagonises isoprenaline-induced decrease in [Mg^<2+>]_i, considered to be an important risk factor in myocardial infarction. Also, recently [Mg^<2+>]_i in carotid artery smooth muscle has successfully measured.In 1999, the head investigator, S. Nakayama was invited to give a talk in two Japanese scientific meetings. Also, In The Gordon Research Conference, Magnesium in Biological Processes and Medicine (Ventura, California, U.S.A.), S. Nakayama was invited as a chairman. In those meetings, S. Nakayama together with Watanabe and Amano, presented recent data regarding the hormonal regulation of intracellular Mg^<2+> regulation in cardiac and smooth muscles, and emphasised importance of Mg^<2+> under physiological and pathological conditions.Lastly, the year 1998 was a special year, marked by 'Festival UK 98' in Japan. The British Council and British Embassy, Tokyo found S. Nakayama on a list of Monbusho's international research collaboration grants, and asked to organise a scientific lecture series. Thus, Nakayama invited Joseph F. Clark, Peter W. Flatman (Department of Physiology, Edinburgh University) and Thomas T. Cunnane (Department of Pharmacology, Oxford) to Japan, and organised a lecture series entitled 'Festival UK 98 Lecture Series B : Biology and Medicine'. This series of lectures was held in Kanazawa, Gifu, Nagoya and Tokyo. Less

在Monbusho和JSPS的国际合作赠款期间，Shinsuke Nakayama（首席研究员）四次访问牛津大学。S. Nakayama与Alison F.约瑟夫·布拉丁放大图片作者：Lorraine M. Smith和Shun-ichi Kajioka的研究，并检测了Mg^<2+>对离体平滑肌细胞膜电流的影响。关于这项电生理学研究，已发表了一篇论文。此外，中山在牛津大学期间，Smith在一篇描述拟交感神经药和拟副交感神经药对心脏细胞内Mg^2+浓度（[Mg^2+]_j）的相互作用的论文中提供了许多有用的评论。另一方面，在日本，松原达昭、天野哲也、野村秀树和S。Nakayama使用核磁共振检查了各种激素对心脏和血管中细胞内Mg 2+调节的影响。这项核磁共振研究的一个新发现是， ...更多信息拮抗异丙肾上腺素诱导的[Mg^<2+>]_i降低，[Mg^<2+>]_i被认为是心肌梗死的重要危险因素。1999年，美国人S.中山先生应邀在两次日本科学会议上发表演讲。另外，在Gordon研究会议，生物过程和医学中的镁（Ventura，加州，美国）中，S.中山被邀请担任主席。在这些会议上，S。Nakayama与Watanabe和Amano一起介绍了关于心脏和平滑肌细胞内Mg^2+调节的激素调节的最新数据，并强调了Mg^2+在生理和病理条件下的重要性。英国理事会和英国驻东京大使馆找到了S。中山在文部省的国际研究合作赠款名单上，并要求组织一个科学讲座系列。因此，中山邀请约瑟夫F。Peter W. Flatman和托马斯T. Cunnane（牛津大学药理学系）前往日本，并组织了题为“英国98年节系列讲座B：生物学和医学”的系列讲座。这一系列讲座在金泽、岐阜、名古屋和东京举行。少