Physiological Relevance ofIntracellular Magnesium

在Monbusho和JSPS的国际合作资助期间，shinsuke Nakayama（首席研究员）四次访问牛津大学。Nakayama与Alison F. Brading, Joseph F. Clark, Lorraine M. Smith和shunun -ichi Kajioka一起研究了Mg^<2+>对分离的平滑肌细胞膜电流的影响。关于这一电生理研究，已经发表了一篇论文。此外，中山在牛津期间，L.M. Smith对一篇描述拟交感和副拟交感药物对心脏细胞内Mg^<2+>浓度（[Mg^<2+>]_j）的相互作用的手稿提供了许多有益的评论。这篇论文也发表在科学杂志上。另一方面，在日本，Tatsu-aki Matsubara, Tetsuya Amano， Hideki Nomura和S. Nakayama利用核磁共振研究了各种激素对心脏和血管细胞内Mg2+调节的影响。这项核磁共振研究的一个新发现是，胰岛素可以拮抗异丙肾上腺素诱导的[Mg^<2+>]_i的降低，而[Mg^<2+>]_i被认为是心肌梗死的一个重要危险因素。此外，最近成功地测量了颈动脉平滑肌中的[Mg^<2+>]_i。1999年，首席研究员中山（S. Nakayama）受邀在两次日本科学会议上发表演讲。此外，在戈登研究会议，镁在生物过程和医学（文图拉，加州，美国），S. Nakayama被邀请为主席。在这些会议上，S. Nakayama与Watanabe和Amano一起介绍了关于心脏和平滑肌细胞内Mg^<2+>调节的激素调节的最新数据，并强调了Mg^<2+>在生理和病理条件下的重要性。最后，1998年是一个特殊的年份，日本举办了“98年英国庆典”。英国文化协会和英国驻东京大使馆在文宝所的国际研究合作资助名单上发现了中山先生，并要求他组织一个科学系列讲座。因此，中山邀请了Joseph F. Clark, Peter W. Flatman（爱丁堡大学生理学系）和Thomas T. Cunnane（牛津大学药学系）来日本，并组织了一个名为“98年英国节日讲座系列B：生物学和医学”的系列讲座。该系列讲座分别在金泽、岐阜、名古屋和东京举行。少

During the tenure of the international collaboration grants from Monbusho and JSPS, shinsuke Nakayama (Head Investigator) four times visited Oxford University. S. Nakayama worked together with Alison F. Brading, Joseph F. Clark, Lorraine M. Smith and Shun-ichi Kajioka, and examined the effects of Mg^<2+> on membrane currents in isolated smooth muscle cells. On this electrophysiological study, one paper has been published. Also, during Nakayama was staying in Oxford, L.M. Smith provided many useful comments on a manuscript describing about the interaction of sympathomimetic and parasympathomimetic drugs on intracellular Mg^<2+> concentration ([Mg^<2+>]_j) in heart. This paper has also appeared in s scientific journal.On the other hand, in Japan end, Tatsu-aki Matsubara, Tetsuya Amano, Hideki Nomura and S. Nakayama examined various hormonal effects on intracellular Mg2+ regulation in heart and blood vessels using nuclear magnetic resonance. A novel finding in this NMR study is that insul … More in antagonises isoprenaline-induced decrease in [Mg^<2+>]_i, considered to be an important risk factor in myocardial infarction. Also, recently [Mg^<2+>]_i in carotid artery smooth muscle has successfully measured.In 1999, the head investigator, S. Nakayama was invited to give a talk in two Japanese scientific meetings. Also, In The Gordon Research Conference, Magnesium in Biological Processes and Medicine (Ventura, California, U.S.A.), S. Nakayama was invited as a chairman. In those meetings, S. Nakayama together with Watanabe and Amano, presented recent data regarding the hormonal regulation of intracellular Mg^<2+> regulation in cardiac and smooth muscles, and emphasised importance of Mg^<2+> under physiological and pathological conditions.Lastly, the year 1998 was a special year, marked by 'Festival UK 98' in Japan. The British Council and British Embassy, Tokyo found S. Nakayama on a list of Monbusho's international research collaboration grants, and asked to organise a scientific lecture series. Thus, Nakayama invited Joseph F. Clark, Peter W. Flatman (Department of Physiology, Edinburgh University) and Thomas T. Cunnane (Department of Pharmacology, Oxford) to Japan, and organised a lecture series entitled 'Festival UK 98 Lecture Series B : Biology and Medicine'. This series of lectures was held in Kanazawa, Gifu, Nagoya and Tokyo. Less