Physiological Relevance ofIntracellular Magnesium

在Monbusho和JSPS的国际合作赠款任职期间，首席调查员中山信介曾四次访问牛津大学。S.Nakayama与Alison F.Brading、Joseph F.Clark、Lorraine M.Smith和Shun-ichi Kajioka合作，研究了镁离子对分离的平滑肌细胞膜电流的影响。关于这项电生理学研究，已经发表了一篇论文。此外，在中山逗留牛津期间，L.M.史密斯在一篇手稿中提供了许多有用的评论，该手稿描述了交感和副交感神经药物对心脏细胞内镁离子浓度([mg^&lt；2+&gt；]j)的相互作用。这篇论文也发表在S的科学期刊上。另一方面，在日本，松原达明、天野哲也、野村秀树和中山秀树利用核磁共振技术研究了各种激素对心脏和血管细胞内镁离子调节的影响。核磁共振研究中的一个新发现是Insul…More能拮抗异丙肾上腺素引起的心肌梗死重要危险因素[mg^&lt；2+&gt；]_i的降低。此外，最近还成功地测量了颈动脉平滑肌中的[mg^&lt；2+]_i。1999年，首席研究员S.Nakayama应邀在日本的两次科学会议上发表了演讲。此外，在戈登研究会议上，生物过程和医学中的镁(美国加利福尼亚州文图拉)邀请S.Nakayama担任主席。在这些会议上，S.Nakayama与Watanabe和Amano一起介绍了关于心肌和平滑肌肉细胞内镁离子调节的激素调节的最新数据，并强调了在生理和病理条件下镁离子的重要性。最后，1998年是一个特殊的年份，在日本被称为英国节98。英国文化协会和英国驻东京大使馆发现S.Nakayama在蒙巴霍的国际研究合作资助名单上，并要求组织一系列科学讲座。因此，Nakayama邀请了Joseph F.Clark、Peter W.Flatman(爱丁堡大学生理学系)和Thomas T.Cunnane(牛津大学药理学系)来日本，并组织了一系列讲座，题为“节日英国98系列讲座B：生物学和医学”。这一系列讲座在金泽、岐阜市、名古屋和东京举行。较少

During the tenure of the international collaboration grants from Monbusho and JSPS, shinsuke Nakayama (Head Investigator) four times visited Oxford University. S. Nakayama worked together with Alison F. Brading, Joseph F. Clark, Lorraine M. Smith and Shun-ichi Kajioka, and examined the effects of Mg^<2+> on membrane currents in isolated smooth muscle cells. On this electrophysiological study, one paper has been published. Also, during Nakayama was staying in Oxford, L.M. Smith provided many useful comments on a manuscript describing about the interaction of sympathomimetic and parasympathomimetic drugs on intracellular Mg^<2+> concentration ([Mg^<2+>]_j) in heart. This paper has also appeared in s scientific journal.On the other hand, in Japan end, Tatsu-aki Matsubara, Tetsuya Amano, Hideki Nomura and S. Nakayama examined various hormonal effects on intracellular Mg2+ regulation in heart and blood vessels using nuclear magnetic resonance. A novel finding in this NMR study is that insul … More in antagonises isoprenaline-induced decrease in [Mg^<2+>]_i, considered to be an important risk factor in myocardial infarction. Also, recently [Mg^<2+>]_i in carotid artery smooth muscle has successfully measured.In 1999, the head investigator, S. Nakayama was invited to give a talk in two Japanese scientific meetings. Also, In The Gordon Research Conference, Magnesium in Biological Processes and Medicine (Ventura, California, U.S.A.), S. Nakayama was invited as a chairman. In those meetings, S. Nakayama together with Watanabe and Amano, presented recent data regarding the hormonal regulation of intracellular Mg^<2+> regulation in cardiac and smooth muscles, and emphasised importance of Mg^<2+> under physiological and pathological conditions.Lastly, the year 1998 was a special year, marked by 'Festival UK 98' in Japan. The British Council and British Embassy, Tokyo found S. Nakayama on a list of Monbusho's international research collaboration grants, and asked to organise a scientific lecture series. Thus, Nakayama invited Joseph F. Clark, Peter W. Flatman (Department of Physiology, Edinburgh University) and Thomas T. Cunnane (Department of Pharmacology, Oxford) to Japan, and organised a lecture series entitled 'Festival UK 98 Lecture Series B : Biology and Medicine'. This series of lectures was held in Kanazawa, Gifu, Nagoya and Tokyo. Less