Physiological Relevance of Intracellular Magnesium

细胞内镁的生理相关性

• 批准号: 09044281
• 负责人: NAKAYAMA Shinsuke
• 金额: $ 0.7万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09044281/
• 关键词: Magnesium; Physiology; Cell biology; Calcium channels

During the tenure of this Monbusho's international collaboration grant, Shinsuke Nakayama (Head Investigator) visited the Department of Pharmacology and the Department of Biochemistry, Oxford University, (from 14th August 97 to 17th September 97). Nakayama and the investigators listed (Brading, A. F., Clark, J. F., Smith, L. M. ) examined the effects of MgィイD12+ィエD1 on membrane currents in isolated smooth muscle cells. Also, during Nakayama was staying in Oxford, Lorraine Smith provided many useful comments on a manuscript describing 'Hormonal regulation of intracellular MgィイD12+ィエD1 concentration in heart'. This manuscript has been submitted to a scientific journal.On the other hand, Gail Pyne (Reserach Associate) visited the Department of Physiology, School of Medicine, Nagoya University (form 27th June 97 to 6th July 97). Gail Pyne started experiments regarding the interaction og MgィイD12+ィエD1 and spasminogen. Shinsuke Nakayama, Hideki Nomura and Kenji Kuba supported her work : simultaneous measurements of oxygen consumption and tension development in arterial smooth muscle. Carotid artery used in the experiment was kindly provided from Motonobu Ohtsuki (Nagoya Shokuniku Center). Gail Pyne continued this work in the Department of Biochemistry, Oxford and communicated some of the results in the 5th Annual Meeting of British Neurosurgery Research Group (Drymen, U. K. ).In the 75th Annual Meeting of the Japanese Physiological Society, a symposium entitled 'Magnesium on Nerve and Muscle Physiology' was held in Kanazawa (27th March 98). In the symposium Shinsuke Nakayama communicated some of the results concerning hormonal regulation of intracellular MgィイD12+ィエD1. also, Joseph Clark (investigator) and Peter Flatman (Lorraine Smith's former supervisor : Department of Physiology, Edinburgh) were invited. The titles of their communications were 'Magnesium in vascular smooth muscle contraction' and 'Ion transporters and magnesium homeostasis", respectively.

在Monbusho国际合作资助期间，Shinsuke Nakayama（首席研究员）访问了牛津大学药理学系和生物化学系（97年8月14日至97年9月17日）。 Nakayama 和列出的研究人员（Brading, A. F.、Clark, J. F.、Smith, L. M.）检查了 MgィイD12+ィエD1 对分离平滑肌细胞膜电流的影响。此外，中山在牛津期间，Lorraine Smith 对描述“心脏细胞内 MgィイD12+ィエD1 浓度的激素调节”的手稿提供了许多有用的评论。该手稿已提交给科学期刊。 另一方面，Gail Pyne（研究员）访问了名古屋大学医学院生理学系（97年6月27日至97年7月6日）。盖尔·派恩 (Gail Pyne) 开始了有关 MgィイD12+ィエD1 和痉挛胺原相互作用的实验。 Shinsuke Nakayama、Hideki Nomura 和 Kenji Kuba 支持她的工作：同时测量动脉平滑肌的耗氧量和张力发展。实验中使用的颈动脉由大月元信（名古屋食肉中心）友情提供。盖尔·派恩（Gail Pyne）在牛津大学生物化学系继续这项工作，并在英国神经外科研究组第五届年会上（英国德里门）交流了部分成果。在日本生理学会第75届年会上，在金泽举行了题为“镁对神经和肌肉生理学”的研讨会（98年3月27日）。在研讨会上，Shinsuke Nakayama 传达了有关细胞内 MgィイD12+ィエD1 激素调节的一些结果。此外，约瑟夫·克拉克（研究员）和彼得·弗拉特曼（洛林·史密斯的前导师：爱丁堡生理学系）也受到邀请。他们的交流标题分别是“血管平滑肌收缩中的镁”和“离子转运蛋白和镁稳态”。