New treatment using gene induction and regenerative medicinefor diaphragmatic agenesis

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Intrapulmonary mesenchymal stem cells (MSC) were administered to the rat with nitrophen-induced diaphragmatic hernia. As a result, PCNA positive cells are increased.DNA was extracted from the 20 patients and parents of congenital diaphragmatic hernia. The microdeletion of TCTE3 was detected. This might be the responsible gene for congenital diaphragmatic hernia.Abdominal muscle flap method was performed for the reconstructive surgery in 11 cases with recurrent diaphragmatic hernia. All of the patients showed good outcome.Liver-like cells were induced from SHED. We are just starting to make the sheet of the striated muscle cells derived from SHED.