Mechanism of the spinal deformity of fish born in heavy oil polluted seawater, and rescue with the new detoxification protein

利用鱼类生物测定系统，研究了石油污染引起鱼类脊椎畸形的机理。结果表明，羟基化多环芳烃（OHPAH）在青鳉早期胚胎发育中具有致死作用，并影响鱼鳞细胞的活性。由此推测，引起该鱼畸形的主要毒物是OHPAH。此外，我们还发现了可能成为解毒蛋白候选物的物质。

Using bioassay systems with fishes, we examined the mechanism of spinal deformity of fish by the heavy oil pollution. As a result, hydroxylated polycyclic aromatic hydrocarbons (OHPAH) provided causing death in early embryogenesis of the medaka, and OHPAH influenced the cell activities in fish scales. We suggested that the main substances of poison causing deformity of the fish are OHPAHs. Furthermore, we found the material which could become a candidate of the detoxification protein.