Mechanism of the spinal deformity of fish born in heavy oil polluted seawater, and rescue with the new detoxification protein

重油污染海水中鱼类脊柱畸形的机制及新型解毒蛋白的拯救

• 批准号: 24651044
• 负责人: HAYAKAWA Kazuichi
• 金额: $ 2.58万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24651044/
• 关键词: 生物影響; 骨代謝; 胚発生; 解毒タンパク質; 有害化学物質; 海洋生態; 環境分析; 水産学

Using bioassay systems with fishes, we examined the mechanism of spinal deformity of fish by the heavy oil pollution. As a result, hydroxylated polycyclic aromatic hydrocarbons (OHPAH) provided causing death in early embryogenesis of the medaka, and OHPAH influenced the cell activities in fish scales. We suggested that the main substances of poison causing deformity of the fish are OHPAHs. Furthermore, we found the material which could become a candidate of the detoxification protein.

使用生物测定系统和鱼类，我们通过重油污染研究了鱼脊柱畸形的机制。结果，羟基化的多环芳烃（OHPAH）在Medaka的早期胚胎发生中导致死亡，OHPAH影响了鱼尺中的细胞活性。我们建议导致鱼畸形的毒药的主要物质是ohpah。此外，我们发现了可能成为解毒蛋白候选的材料。

项目成果

Increased Prostaglandin E2 has a positive correlation with plasma calcium during goldfish reproduction

金鱼繁殖过程中前列腺素E2升高与血浆钙呈正相关

• 发表时间: 2014
• 期刊: Journal of the Faculty of Agriculture Kyushu University
• 影响因子: 0.6
• 作者: Suzuki;N.;Maruyama;Y.;Nakano;M.;Hattori;A.;Honda;M.;Shimasaki;Y.;Sekiguchi;T.;Hishima;H.;Wada;S.;Srivastav;A.K.;Hayakawa;K.;Oshima;Y.
• 通讯作者: Y.

のと海洋ふれあいセンターが観測した沿岸水のpH低下について

关于能登海洋联络中心观察到的沿岸水域pH值下降的情况

• 发表时间: 2014
• 期刊: のと海洋ふれあいセンター研究報告
• 作者: 鈴木元気;牧野史弥;早川和一;東出幸真;達克幸;坂井恵一
• 通讯作者: 坂井恵一

Polychlorinated biphenyl disrupts bone metabolism in goldfish

多氯联苯扰乱金鱼的骨代谢

• 发表时间: 2012
• 作者: Yachiguchi;K.;Matsumoto;N.;Haga;Y.;Suzuki;M.;Matsumura;C.;Tsurukawa;M.;Okuno;T.;Nakano;T.;Kawabe;K.;Kitamura;K.;Toriba;A.;Hayakawa;K.;Hattori;A.;Suzuki;N.
• 通讯作者: N.

Static and Dynamic Hypergravity Responses of Osteoblasts and Osteoclasts in Medaka Scales

• DOI: 10.2108/zsj.30.217
• 发表时间: 2013-03
• 作者: S. Yano;K. Kitamura;Y. Satoh;Masaki Nakano;A. Hattori;T. Sekiguchi;M. Ikegame;H. Nakashima;Katsunori Omori;K. Hayakawa;A. Chiba;Y. Sasayama;S. Ejiri;Y. Mikuni‐Takagaki;H. Mishima;H. Funahashi;T. Sakamoto;N. Suzuki

Determination of Calcium Sensing Receptor in the Scales of Goldfish and Induction of Its mRNA Expression by Acceleration Loading

金鱼鳞片钙敏感受体的测定及加速加载诱导其mRNA表达

• DOI: 10.2187/bss.26.26
• 发表时间: 2012
• 期刊: Biological Sciences in Space
• 作者: Kakikawa;M.;Yamamoto;T.;Chowdhury;V.S.;Satoh;Y.;Kitamura;K.;Sekiguchi;T.;et al.
• 通讯作者: et al.