Mechanism of the spinal deformity of fish born in heavy oil polluted seawater, and rescue with the new detoxification protein

利用鱼类生物检测系统，对重油污染致鱼类脊柱畸形的机理进行了研究。结果表明，羟化多环芳烃(OHPAH)可导致青竹胚胎早期死亡，OHPAH影响鱼鳞中的细胞活性。我们认为，引起鱼类畸形的主要毒物是OHPAHs。此外，我们还找到了可能成为解毒蛋白候选者的材料。

Using bioassay systems with fishes, we examined the mechanism of spinal deformity of fish by the heavy oil pollution. As a result, hydroxylated polycyclic aromatic hydrocarbons (OHPAH) provided causing death in early embryogenesis of the medaka, and OHPAH influenced the cell activities in fish scales. We suggested that the main substances of poison causing deformity of the fish are OHPAHs. Furthermore, we found the material which could become a candidate of the detoxification protein.