Roles of 53BP1 in elimination of an apoptotic cell

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p53 binding protein-1(53BP1) accumulates at sites of DNA double-strand breaks, where it suppresses DNA end resection, and facilitates repair of DNA double-strand breaks by non-homologous end joining. In this study, we found that in apoptotic cells 53BP1 is cleaved to generate a fragment of 53BP1 in a caspase-dependent manner. This 53BP1 fragment is localized on the surface of apoptotic cells. Our data suggest that 53BP1 regulates clearance of apoptotic cells by a macrophage.