Analysis of the possible contribution of perichromosomal field to the chromosomal stability

每条有丝分裂染色体周围的外层，我们称之为PCF，即“染色体周围区”，是一个功能未知的细胞区域。基于对Ki67抗原（PCF的主要成分）的功能分析，我们发现PCF可能参与有丝分裂过程的“质量”。PCF似乎通过为PP1 γ等因子提供一个“场”来促进有丝分裂的有效进展；（蛋白磷酸酶1 γ）在适当的时间定位在有丝分裂的染色体上。PCF可能还具有从外部支持有丝分裂染色体结构的功能。

The outer layer around each mitotic chromosome, which we call PCF for 'perichromosomal field', is a cellular region with unknown functions. Derived from the knowledge obtained from the functional analyses of Ki67 antigen, a major constituent of PCF, we showed the possibility that the PCF might be involved in the 'quality' of the progression of mitosis. The PCF seems to contribute to the efficient progression of mitosis by providing a 'field' for factors such as PP1 gamma; (protein phosphtase 1 gamma;) to localize on mitotic chromosomes in appropriate timing. The PCF might have function also in supporting the structure of mitotic chromosomes from their outside.