Role of ADP ribosyl cyclase in pathogenesis of preeclampsia

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Pre-eclampsia (PE), hypertension and proteinuria developing after 20 weeks of gestation, is the cause of maternal and fetal deaths. The only definitive treatment currently available to save the mother and/or the baby is induced delivery. Anti-hypertensives acceptable for use during pregnancy help control maternal blood pressure in PE, but they do not prevent pre-term delivery nor correct the fetal growth restriction associated with PE. We have demonstrated that nicotinamide reduces the hypertension and proteinuria in mice having a pre-eclampsia-like condition, delays miscarriages and alleviates the fetal growth restriction. Nicotinamide is the first substance that benefits both mother and offspring by targeting a pathway specifically dysfunctional in PE. It merits evaluation for preventing or treating PE in humans.