The mechanisms of placebo effect on orofacial pain

安慰剂对口面部疼痛的作用机制

• 批准号: 24659831
• 负责人: KOBAYASHI Masayuki
• 金额: $ 2.41万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659831/
• 关键词: プラシーボ; 疼痛; 大脳皮質; 下歯槽神経; モデル動物; 島皮質; PET; 覚醒; 侵害刺激

The present study aimed to explore the activated brain regions responding to placebo effect in a model with orofacial pain. The experiments were divided into two steps: (1) establishment of the model for orofacial chronic pain that is suitable for estimation of placebo effect, and (2) PET imaging to estimate the activated brain regions in awake model rats. We found that the model with inferior alveolar nerve injury is suitable for this study. Furthermore, our PET imaging revealed that orofacial pain principally activated the primary somatosensory cortex.

本研究旨在探讨口面疼痛模型中安慰剂效应对脑区的激活作用。实验分两步进行：（1）建立适合于安慰剂效应评估的口面慢性疼痛模型;（2）PET显像评估清醒模型大鼠的激活脑区。结果表明，下牙槽神经损伤模型是一种较理想的动物模型。此外，我们的PET成像显示，口面疼痛主要激活初级躯体感觉皮层。

项目成果

CHOLINERGIC INTERNEURONS SUPPRESS ACTION POTENTIAL INITIATION OF MEDIUM SPINY NEURONS IN RAT NUCLEUS ACCUMBENS SHELL

• DOI: 10.1016/j.neuroscience.2013.01.012
• 发表时间: 2013-04-16
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Ebihara, K.;Yamamoto, K.;Kobayashi, M.
• 通讯作者: Kobayashi, M.

Changes in expression of growth-associated protein-43 in trigeminal ganglion neurons and of the jaw opening reflex following inferior alveolar nerve transection in rats.

• DOI: 10.1111/eos.12021
• 发表时间: 2013-04
• 期刊: European journal of oral sciences
• 影响因子: 1.9
• 作者: Kohei Teramoto;Y. Tsuboi;M. Shinoda;S. Hitomi;K. Abe;K. Kaji;Takaaki Tamagawa;Azumi Suzuki;N. Noma;Masayuki Kobayashi;O. Komiyama;K. Urata;K. Iwata

Phenotypic characterisation of orofacial movement topography in mutants with disruption of amino acid mechanisms : glutamate N2A/B/D [GluRε1/2/4] subtypes and the GABA synthesising enzyme GAD65

氨基酸机制破坏的突变体口面部运动地形的表型特征：谷氨酸 N2A/B/D [GluRε1/2/4] 亚型和 GABA 合成酶 GAD65

• 发表时间: 2013
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Tomiyama K;Kato R;Hara Y;Kobayashi M;Mishina M;Yanagawa Y;Kinsella A;Koshikawa N;Waddington JL
• 通讯作者: Waddington JL

Fast-spiking Cell to Pyramidal Cell Connections Are the Most Sensitive to Propofol-induced Facilitation of GABAergic Currents in Rat Insular Cortex

• DOI: 10.1097/aln.0000000000000183
• 发表时间: 2014-07-01
• 期刊: ANESTHESIOLOGY
• 影响因子: 8.8
• 作者: Koyanagi, Yuko;Oi, Yoshiyuki;Kobayashi, Masayuki
• 通讯作者: Kobayashi, Masayuki

Reciprocal regulation of inhibitory synaptic transmission by nicotinic and muscarinic receptors in rat nucleus accumbens shell.

大鼠伏隔核壳中烟碱和毒蕈碱受体对抑制性突触传递的相互调节。

• DOI: 10.1113/jphysiol.2013.258558
• 发表时间: 2013
• 期刊: J Physiol
• 作者: Yamamoto K;Ebihara K;Koshikawa N;Kobayashi M
• 通讯作者: Kobayashi M