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Designing protein-incorporating scaffolds for periodontal tissue engineering

Designing protein-incorporating scaffolds for periodontal tissue engineering
设计用于牙周组织工程的蛋白质掺入支架
批准号：
24659877
负责人：
KATO Koichi
金额：
$2.41万
依托单位：
Hiroshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659877/
关键词：
骨再生歯周組織タンパク質工学細胞増殖因子組織工学再生医療間葉系幹細胞サイトカインスキャホールドタンパク質骨分化タンパク質アレイ

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英文摘要
Recently much attention has been paid to periodontal tissue regeneration using mesenchymal stem cells and biodegradable scaffolds. One of the most important challenges at this moment is to accelerate the formation of new bone tissues. In this study, we screened various growth factors and their combinations to identify the best factors to be incorporated into scaffolds for the enhanced bone formation. As a result, we found that incorporation of BMP-2 into scaffold materials is most effective for the preparing bone tissue scaffolds. Further study was carried out to identify peptides that have an affinity for biodegradable polymer scaffolds. As a result, it was found that the peptide having a specific sequence exhibited an affinity for poly(lactic acid). According to this result, we propose that, when fused with a growth factor, this peptide would be effective for constructing growth factor/scaffold composites.
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Methodological Research for Reconstruction of History of Western Architecture and Theory of Architectural Design based on Tectonics and Materiality
  • 批准号：
    19H02328
  • 项目类别：
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  • 资助金额：
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  • 财政年份：
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  • 批准号：
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  • 项目类别：
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  • 资助金额：
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  • 财政年份：
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  • 负责人：
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