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Designing tissue engineering scaffolds for neural stem cell transplantation through protein engineering

Designing tissue engineering scaffolds for neural stem cell transplantation through protein engineering
通过蛋白质工程设计用于神经干细胞移植的组织工程支架
批准号：
19300171
负责人：
KATO Koichi
金额：
$12.31万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2007
资助国家：
日本
项目状态：
已结题
起止时间：
2007 至 2009
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19300171/
关键词：
キメラタンパク質再生医療中枢神経細胞増殖因子幹細胞移植バイオマテリアルハイドロゲル自己組織化コイルドコイル神経幹細胞細胞接着組織工学細胞移植

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中文摘要
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英文摘要
This project was aimed at developing protein-based biomaterials that serve to improve the survival and engraftment of neural stem/progenitor cells transplanted into central nervous tissues for therapeutic purposes. It was shown that hydrogels made of naturally-occurring polymers such as collagen and hyaluronic acid could be suitably used as base materials. In addition, protein engineering strategies were employed to incorporate growth factors, neurotrophic factors, and/or integrin binding polypeptide domains into the base materials. We demonstrated that such approaches were quite effective for improving survival of cells embedded in the hydrogels.
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Surface-anchoring of spontaneously diraerized epidermal growth factor for highly selective expansion of neural
自发二化表皮生长因子的表面锚定用于神经的高度选择性扩张
DOI： --
发表时间： 2009
期刊： Bioconjugate Chemistry 20
影响因子： --
作者： [T. Nakaji-Hirabayashi, K. Kato, H. Iwata]
通讯作者： H. Iwata
Enhanced Survival of Neural Cells Embedded in Hydrogels Composed of Collagen and Laminin-Derived Cell Adhesive Peptide
DOI： 10.1021/bc9000068
发表时间： 2009-05-01
期刊： BIOCONJUGATE CHEMISTRY
影响因子： 4.7
作者： [Hiraoka, Makiko, Kato, Koichi, Iwata, Hiroo]
通讯作者： Iwata, Hiroo
Surface-displayed antibodies as a tool for simultaneously controlling the arrangement and morphology of multiple cell types with microscale precision
表面展示抗体作为以微米级精度同时控制多种细胞类型的排列和形态的工具
DOI： --
发表时间： 2009
期刊： ACS Applied Materials and Interfaces 1
影响因子： --
作者： [Hiroko Miyazaki, Takeshi Maki, Koichi Kato, Hiroo Iwata]
通讯作者： Hiroo Iwata
Surface-anchoring of genetically-engineered growth factors onto substrates for their efficient presentation toward cells
将基因工程生长因子表面锚定在基质上，以使其有效地呈现给细胞
DOI： --
发表时间： 2009
期刊：
影响因子： --
作者： [Koichi Kato, Tadashi Nakaji-Hirabayashi, Shuhei Konagaya, Hiroo Iwata]
通讯作者： Hiroo Iwata
共 22 条
    Methodological Research for Reconstruction of History of Western Architecture and Theory of Architectural Design based on Tectonics and Materiality
    • 批准号：
      19H02328
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $4.33万
    • 财政年份：
      2019
    • 负责人：
      KATO Koichi
    • 依托单位：
      The University of Tokyo
    Diabetic neuropathy, endoplasmic reticulum stress and autophagy.
    • 批准号：
      18K06763
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.58万
    • 财政年份：
      2018
    • 负责人：
      KATO Koichi
    • 依托单位：
      Aichi Gakuin University
    Elucidation of structural basis of glycoconjugate functions and its application for molecular design toward developing drugs targeting the carbohydrate recognition systems
    Identification and structural-functional analysis of shuttle-type proteasome activator exhibiting molecular chaperone activity
    海外基金