Synthesis of Chondrochloren A

软骨氯烯A的合成

• 批准号: 397324012
• 负责人: Professor Dr. Markus Kalesse
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/397324012?language=en
• 关键词: Synthesis; Chondrochloren

This project aims at the first total synthesis chondrochloren. The most prominent structural features of the chondrochlorens are a rare Z-Enamide unit and a polyoxygenated middle fragment. Both fragments are synthetically challenging and we plan to establish synthetic solutions within this project. As the pivotal transformation the Ullmann-Goldberg coupling joins the polyoxygenated fragment with the aromatic fragment and established the challenging Z-Enamide.

该项目旨在首个总合成软骨菌。软骨菌最突出的结构特征是稀有的Z-纳米酰胺单元和多氧中间片段。这两个碎片在综合上都具有挑战性，我们计划在该项目中建立合成解决方案。当关键转化时，Ullmann-Goldberg耦合将多氧片段与芳香族片段相连，并确定了具有挑战性的Z-烯酰胺。

项目成果

Towards the total synthesis of chondrochloren A: synthesis of the (Z)-enamide fragment

• DOI: 10.3762/bjoc.16.64
• 发表时间: 2020-04-14
• 期刊: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
• 影响因子: 2.7
• 作者: Geldsetzer, Jan;Kalesse, Markus
• 通讯作者: Kalesse, Markus