Role of endothelial ADAR1 in vascular growth and homeostasis (B12*)

内皮 ADAR1 在血管生长和稳态中的作用 (B12*)

• 批准号: 397831829
• 金额: --
• 依托单位: European Center for Angioscience (ECAS)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/397831829?language=en
• 关键词: Role; endothelial; ADAR1; vascular; growth

ADAR1 catalyses the editing of adenosine-to-inosine in double-stranded RNAs. The milestones of this proposal are to identify of the role of ADAR1 in vascular development and homeostasis in vivo. We have already observed that endothelial ADAR1 is indispensable for vascular growth and homeostasis in vivo. Therefore, we will now fully characterize the phenotype of EC-deficient ADAR1 mice and delineate the underlying molecular mechanisms.

ADAR 1催化双链RNA中腺苷到肌苷的编辑。该计划的里程碑是确定ADAR 1在体内血管发育和稳态中的作用。我们已经观察到，内皮ADAR 1是不可缺少的血管生长和体内稳态。因此，我们现在将充分表征EC缺陷型ADAR 1小鼠的表型，并描绘潜在的分子机制。