Biofabrication of heart substitute tissue based on bioink from spider silk proteins (C01)

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Heart diseases are a major socioeconomic burden. Despite considerable progress in the prevention and minimization of heart damage, the prevalence of heart insufficiency increases continuously. The aim of this subproject is the reproducible production of hierarchically organized human cardiac substitute tissue using 3D printing technology. For this purpose, hiPSC-derived cardiac cells, spider silk proteins developed during the first funding period, aligned fibers, and perfusable tubular structures will be used. The long-term goal is the treatment of heart diseases.