The importance of polyamine activation in pulmonary hypertension

多胺活化在肺动脉高压中的重要性

• 批准号: 15K15318
• 负责人: SAKAI Satoshi
• 金额: $ 2.33万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15K15318/
• 关键词: 肺高血圧症; ポリアミン; メタボローム解析

项目成果

Effects of endothelin receptor antagonists on doxorubicin-induced apoptosis in vascular smooth muscle cells derived from human pulmonary artery

内皮素受体拮抗剂对阿霉素诱导的人肺动脉血管平滑肌细胞凋亡的影响

• 发表时间: 2015
• 作者: Sakai S;et al
• 通讯作者: et al

Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension

• DOI: 10.1016/j.healun.2014.09.011
• 发表时间: 2015-03-01
• 期刊: JOURNAL OF HEART AND LUNG TRANSPLANTATION
• 影响因子: 8.9
• 作者: Maruyama, Hidekazu;Dewachter, Celine;Dewachter, Laurence
• 通讯作者: Dewachter, Laurence

Hypoxia induces the down regulation of the BMP signaling in pulmonary artery smooth muscle cells through the endothelin system

缺氧通过内皮素系统诱导肺动脉平滑肌细胞中 BMP 信号的下调

• 发表时间: 2016
• 作者: Maruyama H;Sakai S;Naeije R;Dewachter L;Aonuma K
• 通讯作者: Aonuma K

Lysol oxidase was increased by endothelin-1 and restored by PGI2 in pulmonary artery smooth muscle cells

肺动脉平滑肌细胞中来苏尔氧化酶被内皮素-1 增加并被 PGI2 恢复

• 发表时间: 2016
• 作者: Maruyama H;Sakai S;Naeije R;Dewachter L;Aonuma K
• 通讯作者: Aonuma K

The decrease of S-wave amplitude in V5 lead of electrocardiography positively reflects effectual treatment in patients with pulmonary hypertension

心电图V5导联S波振幅降低积极反映肺动脉高压患者治疗有效

• 发表时间: 2017
• 作者: Otsu K;Sakai S;Kimura T;Miyauchi T;Homma S;Aonuma K
• 通讯作者: Aonuma K