The mechanism for blood pressure elevation in newly developed obesity mouse and the application for the prevention and treatment of hypertension

新培育的肥胖小鼠血压升高的机制及其在防治高血压中的应用

• 批准号: 22500656
• 负责人: SAKAI Satoshi
• 金额: $ 2.75万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500656/
• 关键词: 肥満; 高血圧; SQSTM1; 生活習慣病; レプチン

We generated conventional knockout mice (KO) of sequestosome1/A170, the molecule related to oxidative stress. KO exhibited the phenotype of obesity and impaired glucose tolerance due to hyperphagia and leptin resistance. We evaluated hemodynamics by telemetry system under no restrictions. During resting time, blood pressure (BP) and pulse rate was higher in KO compared to wild type (WT) though it did not differ during active time, indicating that KO shows the BP pattern of non-dipper type of hypertension. The urine amount of excreted catecholamine was significantly higher in KO than WT, suggesting that increase of the sympathetic nerve activity contributes to the BP elevation in KO.

我们产生了传统的敲除小鼠（KO）的螯合体1/A170，与氧化应激相关的分子。KO表现出肥胖和糖耐量受损的表型，由于摄食过多和瘦素抵抗。我们在不受限制的情况下通过遥测系统评估血流动力学。在静息时间，KO中的血压（BP）和脉率高于野生型（WT），尽管在活动时间没有差异，表明KO显示非杓型高血压的BP模式。KO组尿中排出的儿茶酚胺量显著高于WT组，提示KO组交感神经活动增加与血压升高有关。

项目成果

DEFICIENCY OF SEQUESTOSOME1/P62/A170 IN MICE IS ASSOCIATED WITH METABOLIC SYNDROME : (II) ENHANCED NEOINTIMAL HYPERPLASIA AND CAROTID ARTERY REMODELING

小鼠中 Sequestosome1/P62/A170 的缺乏与代谢综合征相关：(II) 增强的新生内膜增生和颈动脉重塑

• 发表时间: 2010
• 作者: H.Harada;E.Warabi;T.Matsuki;K.Okada;T.Yanagawa;T.Sakurai;T.Ishii
• 通讯作者: T.Ishii

Roles of sequestosome1/p62 in prevention of obesity, hypertension and atherosclerosis.

Sequestosome1/p62 在预防肥胖、高血压和动脉粥样硬化中的作用。

• 作者: 熊坂謙一;麻生順子;羽田千香子;宮澤眞紀;小島尚;内山奈穂子;鎌倉浩之;合田幸広;Ishii T
• 通讯作者: Ishii T

Suppressor of Cytokine Signaling 1 DNA Administration Inhibits Inflammatory and Pathogenic Responses in Autoimmune Myocarditis

• DOI: 10.4049/jimmunol.1103610
• 发表时间: 2012-08-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Tajiri, Kazuko;Imanaka-Yoshida, Kyoko;Yasutomi, Yasuhiro
• 通讯作者: Yasutomi, Yasuhiro

Roles of sequestosome1/p62 in prevention of obesity, hypertension and atherosclerosis

Sequestosome1/p62 在预防肥胖、高血压和动脉粥样硬化中的作用

• 发表时间: 2012
• 作者: Ishii T;Warabi E;Sakai S;Yanagawa T
• 通讯作者: Yanagawa T

Possible involvement of SREBP-1 in the cardiac dysfunction via reduction of antioxidant gene

SREBP-1 可能通过减少抗氧化基因参与心脏功能障碍

• 发表时间: 2010
• 作者: Sakai S;Shimojo N;他4名
• 通讯作者: 他4名