Ultrafast monitoring and synthetic control of electronic properties of a self-assembled coordination system as a multi-site luminescent probe for sensoric and imaging applications

作为传感和成像应用的多位点发光探针的自组装协调系统的电子特性的超快监测和综合控制

• 批准号: 404530043
• 负责人: Professor Dr. Bernd Abel
• 金额: --
• 依托单位: Institut für Anorganische Chemie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/404530043?language=en
• 关键词: Ultrafast; monitoring; synthetic; control; electronic

The present approach aims at a novel strategy to develop molecular fluorescent probes with more than one site for molecular or ion recognition. We propose a novel design concept for a multi-site fluorescence probe that enables a multiplex or logic system response or the control and switching of sensor features, much beyond those observed in conventional molecular probes, requiring advanced synthesis guided by ultrafast spectroscopy and theory. The target compounds, constructed in a modular approach by metal-templated Schiff-base reactions, contain two selective binding sites, which constitute an integral part of a central salicyclidene-aldimine chromophore unit. Transition metal binding (Zn2+, Cu+) at site A enhances the fluorescence, while occupation of site B (Li+, Na+, K+) modulates the fluorescence properties. The system responses are monitored with photoelectron emission spectroscopy from liquid and solid interfaces, continuum probe transient absorption and fluorescence lifetime imaging and the data are interpreted employing density functional theory providing the guidelines for selective synthetic improvements.

本方法旨在开发具有多个分子或离子识别位点的分子荧光探针。我们提出了一种新的设计概念，多位点荧光探针，使多路复用或逻辑系统响应或传感器功能的控制和切换，远远超出了在传统的分子探针中观察到的，需要先进的合成超快光谱和理论指导。目标化合物，构建在一个模块化的方法，通过金属模板的席夫碱反应，包含两个选择性结合位点，这构成了一个中心水杨醛亚胺发色团单元的一个组成部分。过渡金属离子（Zn ~（2+）、Cu ~（2+））在A位的结合增强了荧光，而占据B位（Li ~+、Na ~+、K ~+）则调节了荧光性质。系统响应监测与光电子发射光谱从液体和固体界面，连续探针瞬态吸收和荧光寿命成像和数据进行解释采用密度泛函理论提供的指导方针，选择性的合成改进。