Delineating genetic and environmentally-mediated influences on socioeconomic inequality in children’s cortisol secretion and executive functions

描述遗传和环境介导的对儿童皮质醇分泌和执行功能的社会经济不平等的影响

• 批准号: 407466711
• 负责人: Dr. Laurel Raffington
• 金额: --
• 依托单位: Forschungsbereich Entwicklungspsychologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/407466711?language=en
• 关键词: Delineating; genetic; environmentally; mediated; influences

Cognitive regulatory processes, called executive functions (EF), are closely linked to decision-making, personality, and health across the lifespan. Children’s EF are positively related to their socioeconomic status (SES), which is indicated by parents’ income, education and occupation. SES can be used as an indicator of circumstances of those ‘better off’ and those ‘worse off’ in society, because it correlates with a myriad of environmental conditions that can elicit stress for example. One theory proposes that higher stress in lower SES dysregulates children’s stress hormone secretion, mainly cortisol, thereby impacting their cognitive development. Emerging research, including my own, has found SES-related disparities in cortisol secretion that is associated with their lower cognitive performance. However, these studies have largely neglected genetic effects, even though these relationships are known to be genetically influenced in part. Behavior genetic methods are able to statistically separate environmental and genetic effects by comparing monozygotic and dizygotic twin pairs. Landmark work by Tucker-Drob and Harden provides evidence that in low SES, cognitive ability is almost entirely predicted by environmental factors, whereas high SES environments facilitate children’s ability to select learning experiences that match their genetically influenced interests. Additionally, animal research suggests stress hormones change gene expression involved in cognitive development. It is therefore conceivable that cortisol secretion is part of an underlying mechanism that suppresses gene expression involved in EF development of low SES children.Therefore, the proposed research will examine the following questions: Is cortisol dysregulation in children driven by SES-related stress or genetic effects, or both? To what degree is the association of cortisol secretion with EF attributable to environmental and genetic effects? Is cortisol part of a mechanism of gene-environment interaction on EF development? The hosts, Elliot Tucker-Drob and Paige Harden, are the principal investigators of the Texas Twin Project, with multivariate cortisol secretion and EF data from a projected number of 1000 twin pairs aged 7–15 years available for analysis by the time of arrival. First, we will use behavior genetic models to disentangle the genetic and environmental dimensions of cortisol secretion. Second, we will delineate whether associations of cortisol with EFs derives from a common genetic pathway or shared environmental effects, or some combination of the two. Third, we will explore whether genetic effects interact with SES effects on EFs as a test of gene suppression in low SES. If this is the case, we will investigate whether cortisol secretion may be mechanistically involved in this gene suppression.

认知调节过程，被称为执行功能（EF），与一生中的决策、个性和健康密切相关。儿童EF与社会经济地位（SES）呈正相关，主要表现在父母的收入、教育程度和职业。社会经济地位可以作为社会中“较富裕”和“较贫穷”的环境指标，因为它与无数可能引发压力的环境条件相关。有一种理论认为，低社会经济地位下的高压力会失调儿童的压力激素分泌，主要是皮质醇，从而影响他们的认知发展。包括我自己的研究在内的新兴研究发现，与ses相关的皮质醇分泌差异与他们较低的认知表现有关。然而，这些研究在很大程度上忽略了遗传效应，尽管这些关系在一定程度上受到遗传的影响。行为遗传学方法能够通过比较同卵双胞胎和异卵双胞胎，在统计上分离环境和遗传的影响。塔克-德罗布和哈登的里程碑式研究提供了证据，证明在低社会经济地位下，认知能力几乎完全由环境因素预测，而高社会经济地位环境有助于儿童选择与他们受基因影响的兴趣相匹配的学习经历。此外，动物研究表明，应激激素会改变与认知发育有关的基因表达。因此，可以想象，皮质醇分泌是抑制低社会经济地位儿童EF发育相关基因表达的潜在机制的一部分。因此，提出的研究将探讨以下问题：儿童皮质醇失调是由ses相关的压力或遗传效应驱动的，还是两者兼而有之？皮质醇分泌与EF的关联在多大程度上可归因于环境和遗传影响？皮质醇是EF发育中基因-环境相互作用机制的一部分吗？主持人Elliot Tucker-Drob和Paige Harden是德克萨斯双胞胎项目的首席研究员，他们有来自1000对7-15岁的双胞胎的多变量皮质醇分泌和EF数据，可以在到达时进行分析。首先，我们将使用行为遗传模型来解开皮质醇分泌的遗传和环境维度。其次，我们将描述皮质醇与EFs的关联是否来自共同的遗传途径或共同的环境影响，或两者的某种组合。第三，我们将探索遗传效应是否与SES效应相互作用，作为低SES基因抑制的测试。如果是这样，我们将研究皮质醇分泌是否可能在机制上参与这种基因抑制。

项目成果

Socioeconomic Disadvantage and the Pace of Biological Aging in Children

• DOI: 10.1542/peds.2020-024406
• 发表时间: 2021-06-01
• 期刊: PEDIATRICS
• 影响因子: 8
• 作者: Raffington, Laurel;Belsky, Daniel W.;Harden, K. Paige
• 通讯作者: Harden, K. Paige

Changing environments reveal innovative genetic variation in children’s cortisol responses

不断变化的环境揭示了儿童皮质醇反应的创新遗传变异

• DOI: 10.1101/856658
• 发表时间: 2019
• 期刊: bioRxiv
• 作者: Raffington;Malanchini;Grotzinger;Madole;Engelhardt;Sabhlok;Patterson;Harden;Tucker-Drob
• 通讯作者: Tucker-Drob