Functional assessment of renal pathologies:Diameter mapping of renal tubules using non-invasive magnetic resonance imaging
肾脏病理的功能评估:使用非侵入性磁共振成像进行肾小管直径测绘
基本信息
- 批准号:408765040
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2018
- 资助国家:德国
- 起止时间:2017-12-31 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Although great progress has been obtained in magnetic resonance imaging (MRI) of the kidneys, biopsy is currently still the means of choice for the diagnosis of unclear kidney diseases. In order to reduce the number of biopsies and thus the burden on patients and the risk of complications, a further improvement of the non-invasive diagnostic imaging of kidney pathologies is desirable.In addition to high-resolution MRI of the renal anatomy, functional MRI methods have been developed, for example, to provide information on perfusion, the oxygenation state or diffusion properties and thus also on the microstructure of the kidney.Different kidney pathologies lead to a change of the diameter of the tubules and thus also the microstructure. For example tubular hypertrophy, as caused by diabetes mellitus, is associated with altered tubule diameters. Therefore, especially in acute and chronic renal failure, the diameter of the tubules may be a sensitive parameter for the early detection of renal pathologies. Currently, microstructural changes of the tubular diameters can only be determined by light microscopy of in vitro tissue extracts.The aim of the proposed project is to develop a non-invasive and contrast-free, MRI-based method that provides novel information on the microscopic structure of the renal parenchyma and, in particular, on the diameters of the renal tubules.
尽管肾脏的磁共振成像(MRI)已经取得了很大的进展,但活检目前仍然是诊断不明肾脏疾病的首选手段。为了减少活组织检查的数量,从而减少患者的负担和并发症的风险,需要进一步改进肾脏病理的非侵入性诊断成像。除了肾脏解剖结构的高分辨率MRI之外,已经开发了功能性MRI方法,例如,以提供关于灌注的信息,不同的肾脏病理会导致肾小管直径的变化,从而也会导致微观结构的变化。例如,由糖尿病引起的肾小管肥大与小管直径改变有关。因此,特别是在急性和慢性肾衰竭中,肾小管直径可能是早期检测肾脏病理的敏感参数。目前,肾小管直径的微观结构变化只能通过体外组织提取物的光学显微镜来确定,该项目的目的是开发一种非侵入性和无对比度的基于MRI的方法,提供有关肾实质微观结构的新信息,特别是肾小管直径。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Comparison of PGSE and STEAM DTI acquisitions with varying diffusion times for probing anisotropic structures in human kidneys
不同扩散时间的 PGSE 和 STEAM DTI 采集用于探测人体肾脏各向异性结构的比较
- DOI:10.1002/mrm.28217
- 发表时间:2020
- 期刊:
- 影响因子:3.3
- 作者:Stabinska J;Ljimani A;Frenken M;Feiweier T;Lanzman RS;Wittsack H-J
- 通讯作者:Wittsack H-J
Spectral diffusion analysis of kidney intravoxel incoherent motion MRI in healthy volunteers and patients with renal pathologies
健康志愿者和肾病患者肾脏体素不相干运动 MRI 的光谱扩散分析
- DOI:10.1002/mrm.28631
- 发表时间:
- 期刊:
- 影响因子:3.3
- 作者:Stabinska J;Ljimani A;Zöllner HJ;Wilken E;Benkert T;Limberg J;Esposito I;Antoch G;Wittsack H-J
- 通讯作者:Wittsack H-J
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Professor Dr. Rotem Lanzman其他文献
Professor Dr. Rotem Lanzman的其他文献
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