Total synthesis of arylnaphthalen lignans via a Photo-Dehydro-Diels-Alder reaction as key step

以光脱水-Diels-Alder反应为关键步骤全合成芳基萘木脂素

• 批准号: 410851941
• 负责人: Professor Dr. Pablo Wessig
• 金额: --
• 依托单位: Lehrstuhl für Bioorganische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/410851941?language=en
• 关键词: Total; synthesis; arylnaphthalen; lignans; via

Based on our long-time experiences in the field of preparative photochemistry, especially with the Photo-Dehydro-Diels-Alder reaction, new and efficient total syntheses for selected arylnaphthalen lignans should be developed. Naphthalenophanes are the key intermediates of these synthetic routes. Arylnaphthalen lignans are a structurally diverse class of natural products with great potential, e.g. in cancer therapy. Because the natural sources usually provide only small amounts, there is a great demand in efficient syntheses of these compounds.

基于我们在制备光化学领域的长期经验，特别是在光脱氢-Diels-Alder反应方面，我们应该开发新的高效的芳基萘木脂素的全合成方法。萘酚是这些合成路线的关键中间体。芳基萘木脂素是一类结构多样的天然产物，具有巨大的潜力，例如在癌症治疗方面。由于自然资源通常只提供少量的化合物，因此对这些化合物的有效合成有很大的需求。